Reduction of bone mineral density by gonadotropin-releasing hormone agonist, nafarelin, is not completely reversible at 6 months after the cessation of administration

Acta Obstetricia Et Gynecologica Scandinavica
M Taga, H Minaguchi

Abstract

To determine the reversibility of bone mineral density after the cessation of GnRH agonist treatment for endometriosis. Longitudinal trial with 6-month treatment period and 6-month follow-up. 28 Japanese premenopausal women with endometriosis. Daily dose of 400 micrograms nafarelin was administered for 6 months. The spine bone mineral density was measured by dual energy X-ray absorptiometry, and blood and urinary bone metabolic parameters were analyzed. The decrease of lumbar bone mineral density, which took place during treatment, continued during the first 3 months after the cessation of treatment and did not return to the initial baseline level even at 6 months after the withdrawal of treatment. The biochemical parameters, which showed a state of enhanced bone turnover during nafarelin treatment, almost returned to the pretreatment level 6 months after the termination of treatment. These results indicate that relatively long period of bone metabolic change might be required to alter the actual bone mineral density after GnRH analog administration.

Associated Clinical Trials

Citations

May 20, 1998·Fertility and Sterility·U UlrichC H Chesnut
Aug 15, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R F Valle
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Jun 29, 1999·Pediatric Clinics of North America·B Schroeder, J S Sanfilippo
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