PMID: 6104477Jan 1, 1980Paper

Reduction of cerebrospinal fluid glutamic acid in Huntington's chorea and in schizophrenic patients

Archiv für Psychiatrie und Nervenkrankheiten
J S KimG Krzepinski

Abstract

Glutamic acid levels were investigated in the cerebrospinal fluid and blood serum of patients with schizophrenia, Huntington's chorea, and sciatic nerve compression by lumbar disc protrusion. In the serum the glutamic acid levels were equal in all three groups; in the cerebrospinal fluid (CSF) of schizophrenic and Hungtington's patients, however, the glutamic acid was decreased to almost half that of the lumbar disc group which served as control. Most of the patients were treated with neuroleptic drugs. However, since in one case (the daughter of a Huntington's patient) the CSF glutamic acid was decreased although this woman had had no neuroleptic treatment, it seems more likely that the glutamic acid decrease is due to the disease rather than to the neuroleptic treatment.

References

Jul 1, 1979·Experimental Neurology·R ZaczekJ T Coyle

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Citations

Mar 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·Kenji HashimotoAndrea Schmitt
Jan 28, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·L Hosák, J Libiger
Nov 17, 2015·Biomolecules·Tanya MiladinovicGurmit Singh
Jun 27, 2014·Expert Opinion on Therapeutic Targets·Kenji Hashimoto
Aug 5, 2009·Neuroscience and Biobehavioral Reviews·Dragos IntaPeter Gass
Jun 1, 1989·Journal of Protein Chemistry·J H Nuske, P Hua
Nov 1, 1986·Acta Neurologica Scandinavica·B Engelsen
Oct 31, 1981·The Medical Journal of Australia·P R Sanberg, G A Johnston
Dec 6, 2001·Hippocampus·J W Newcomer, J H Krystal
Apr 28, 2009·Progress in Neurobiology·Robert SchwarczPaul J Muchowski

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