Reduction of cyclosporine dosage with ketoconazole in a patient with birdshot retinochoroidopathy

American Journal of Ophthalmology
B E Silverstein, I G Wong

Abstract

To report the successful reduction of cyclosporine dosage with adjunctive ketoconazole in a patient with birdshot retinochoriodopathy. Case report. A 55-year-old woman treated with cyclosporine for birdshot retinochoroidopathy had ketoconazole (200 mg/day) added to her medical regimen. Her cyclosporine dosage was reduced to 40 mg per day from 200 mg per day, an 80% reduction. No toxic effect was observed during 12 months of follow-up nor was there progression of the birdshot retinochoroidopathy. Cyclosporine dosage may be reduced considerably in patients with uveitis who use adjunctive ketoconazole. The regimen appears to be safe and efficacious.

Citations

Oct 1, 2019·Ocular Immunology and Inflammation·Caiyun YouC Stephen Foster
Mar 10, 2000·Clinical Pharmacokinetics·K VenkatakrishnanD J Greenblatt
Sep 15, 2005·Ocular Immunology and Inflammation·Matthias D BeckerJames T Rosenbaum

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