PMID: 4092862Dec 1, 1985

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

C F GotfredsenE K Frandsen


A group of 36 diabetes-prone BB Wistar rats were given prophylactic insulin treatment with heat-treated bovine ultralente insulin (15 IU X kg-1 X day-1) from 50 to 142 days of age. The incidence of Type 1 (insulin-dependent) diabetes at the end of the treatment period was compared to that of 36 control animals given insulin only from the first day of glycosuria. At withdrawal of the prophylactic insulin treatment, 6 of 36 treated animals were insulin-dependent, while 15 of 36 control animals had developed diabetes (p less than 0.02). One control animal (day 153) and 2 insulin-treated animals (day 172 and 186) subsequently developed diabetes, yielding an overall diabetes incidence of 16 of 36 controls against 8 of 36 insulin treated (p less than 0.05). The finding that prophylactic insulin treatment of diabetes-prone BB Wistar rats reduced the incidence of diabetes suggests a relationship of the immune destruction of B cells to the endogenous insulin production/secretion rate.

Associated Clinical Trials


Mar 1, 1991·Diabetes/metabolism Reviews·C BoitardJ F Bach
Apr 1, 1992·Diabetes/metabolism Reviews·L CrisáA A Rossini
Apr 1, 1992·Diabetes/metabolism Reviews·C Giordano
Dec 1, 1993·Diabetes/metabolism Reviews·U Di Mario, F Dotta
Dec 1, 1993·Diabetes/metabolism Reviews·A G ZieglerW Rabl
Aug 31, 2002·Diabetes/metabolism Research and Reviews·P Pozzilli
Sep 1, 1994·Diabetologia·C BoitardJ F Bach
Dec 1, 1992·Diabetologia·R P Robertson, D J Klein
Oct 1, 1993·Diabetologia·D L GuberskiA A Like
Nov 1, 1989·Indian Journal of Pediatrics·J Ludvigsson
Jan 1, 1997·Indian Journal of Pediatrics·R P Schwartz
Mar 24, 2004·Current Diabetes Reports·Constantin Polychronakos
Jan 1, 1995·Molecular Aspects of Medicine·W J KargesH M Dosch
Jun 20, 1992·Lancet·T BockK Buschard
Jun 1, 1995·Immunology Today·N Schloot, G S Eisenbarth
Nov 1, 1995·Trends in Endocrinology and Metabolism : TEM·A Muir, D Schatz
Aug 2, 2002·Biochemical and Biophysical Research Communications·Anette Amstrup PedersenBirgitte Koch Michelsen
Feb 1, 1996·Metabolism: Clinical and Experimental·H K DriscollA B Pofahl
Sep 1, 1996·Diabetes Research and Clinical Practice·Y KainoK Kida
Mar 21, 2000·Diabetes Research and Clinical Practice·H Y SongR C McEvoy
Dec 2, 2004·Nature Reviews. Immunology·Bart O RoepMatthias von Herrath
Mar 16, 2004·Pediatric Diabetes·D M Wilson, B Buckingham
Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
Nov 24, 1994·The New England Journal of Medicine·M A Atkinson, N K Maclaren
May 31, 2002·The New England Journal of Medicine·Diabetes Prevention Trial--Type 1 Diabetes Study Group
May 1, 1995·The Journal of Experimental Medicine·E LargerC Boitard
Jul 27, 2001·Diabetes Technology & Therapeutics·N AbiruG S Eisenbarth
Jun 25, 2002·Diabetes Technology & Therapeutics·James A Stoever, Jerry P Palmer
Jul 2, 2004·ILAR Journal·J P MordesD L Greiner
Mar 22, 2002·Transplantation·Lijun BaiAnn M Simpson
Oct 1, 1993·Journal of Internal Medicine·F A KarlssonP Burman
Jun 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T W KjaerK Buschard
Sep 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C R PedersenK Buschard

Related Concepts

August Rats
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Process of Secretion
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