Reduction of drug-induced yawning and penile erection and of noncontact erections in male rats by the activation of GABAA receptors in the paraventricular nucleus: involvement of nitric oxide

The European Journal of Neuroscience
M R Melis, A Argiolas

Abstract

The effect of muscimol, a GABAA receptor agonist, injected into the paraventricular nucleus (PVN) of the hypothalamus on drug-induced (apomorphine, oxytocin and NMDA) yawning and penile erection, and on the increase in the concentration of NO2- and NO3- occurring in the paraventricular dialysate in these experimental conditions, was studied in male rats. Muscimol (50, 100 and 200 ng) reduced, in a dose-dependent manner, penile erection and yawning induced by apomorphine (50 ng), oxytocin (30 ng) and NMDA (50 ng) delivered into the PVN. The reduction of penile erection and yawning was parallel to a reduction of the concomitant NO2- and NO3- increase that occurs in the paraventricular dialysate in this experimental condition. In contrast, baclofen (200 ng), a GABAB receptor agonist, was ineffective. The muscimol effects on drug-induced penile erection, yawning and NO2- increase were prevented by the prior administration of bicuculline (250 ng into the paraventricular nucleus). Muscimol (200 ng) but not baclofen (200 ng), injected into the PVN, reduced both noncontact erections in male rats placed in the presence of an inaccessible receptive female, and also the NO2- increase that occurs in the paraventricular dialysate in this ex...Continue Reading

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Citations

Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Salvatora SuccuAntonio Argiolas
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Aug 28, 2003·Journal of Anti-aging Medicine·Marios Kyriazis
Aug 31, 2010·Research in Veterinary Science·M M BernardiH Manzano
Mar 19, 2008·Journal of Clinical Anesthesia·Chih-Hsiang TsouHeidi M Koenig
Jun 15, 2007·Research in Veterinary Science·Patricia S B Rodrigues-AlvesHelenice de S Spinosa
Jul 27, 2005·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Oct 19, 2004·Physiology & Behavior·Antonio Argiolas, Maria Rosaria Melis
Sep 22, 2011·The Annals of Pharmacotherapy·Edna Patatanian, Nancy Toedter Williams
Apr 3, 2003·The European Journal of Neuroscience·Maria Rosaria MelisAntonio Argiolas
Jan 1, 2003·World Journal of Gastroenterology : WJG·Dong-Ping XieKe-Jing Liu
Feb 18, 2020·Revista Internacional De Andrología·Babak Hosseinzadeh ZoroufchiAbolfazl Abdollahpour

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