PMID: 11905589Mar 22, 2002Paper

Reduction of free radical activity in amyloid deposits following liver transplantation for familial amyloidotic polyneuropathy

Journal of Internal Medicine
N NyhlinO Suhr

Abstract

Liver transplantation halt the progress of familial amyloidotic polyneuropathy (FAP). Oxidative stress has been implicated in amyloid toxicity and formation. The objective of this study was to establish whether markers for oxidant stress and antioxidant capacity change following liver transplantation in patients with FAP. Morphometric and biochemical study. Tertiary referral centre. Duodenal biopsy samples from 16 patients, taken before and after liver transplantation were used for morphometry. Serum samples from 14 patients, seven of whom had received transplants, were analysed regarding antioxidant capacity. Liver transplantation. Immunohistochemistry was used to stain for the lipid peroxidation product 4-hydroxynonenal (HNE), and Congo red staining was used for amyloid detection. Positive areas were quantified by point counting. Total antioxidant capacity (TAC) was measured with a colourimetric assay. In tissue, a decrease of HNE was noted after liver transplantation, whereas no significant changes were detected for amyloid deposits. No difference between transplanted and not transplanted patients was noted for total antioxidant capacity measured in serum. To our knowledge, this is the first description of a reduction of mar...Continue Reading

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Citations

May 19, 2010·Autonomic Neuroscience : Basic & Clinical·Urban WiklundOle B Suhr
Mar 4, 2005·Journal of Cellular Physiology·Jikui ShenPeter A Campochiaro
Dec 9, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andreia CarvalhoLuísa Lobato
May 7, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Jonas WixnerIntissar Anan
Aug 4, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·N MatsunagaO B Suhr

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