PMID: 8944403Nov 1, 1996Paper

Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs

Psychopharmacology
H E MolewijkB Olivier

Abstract

Guinea pigs possess central 5-HT1D receptors similar to humans but different from rats and mice. In order to study the role of this receptor on animal behaviour, it may be of interest to develop a paradigm measuring affective states in the guinea pig. Therefore we assessed the effects of a variety of psychotropic drugs on guinea pig pup isolation calls. Anxiolytic compounds such as the benzodiazepine receptor agonists diazepam and alprazolam, the full 5-HT1A receptor agonists 8-OH-DPAT and flesinoxan, and alcohol reduced isolation calling by the guinea pig pup. Moreover, mixed antidepressant/anxiolytic compounds like the 5-HT uptake inhibitors fluvoxamine and clomipramine or the MAO-inhibitor clorgyline as well as the antidepressant NA uptake inhibitors desipramine and maprotiline suppressed vocalizations. The 5-HT1D/1A receptor agonist 5-CT was also very effective in reducing separation calls. Remarkably, the partial 5-HT1A receptor agonists buspirone and BMY 7378 did not affect calling. The neuroleptic haloperidol, the psychostimulant d-amphetamine, the putative anxiogenics DMCM and m-CPP and the putative anxiolytics ondansetron and CI-988 had no effect on isolation calls of guinea pig pups. We propose this paradigm could be ...Continue Reading

Citations

Mar 22, 2005·Psychopharmacology·Matthew W Feltenstein, Kenneth J Sufka
Jul 6, 2006·Amino Acids·K Ebner, N Singewald
Jul 29, 2000·European Journal of Pharmacology·J A BouwknechtB Olivier
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·M B HennessyA J Farré
Feb 16, 2000·Psychoneuroendocrinology·L Martínez-MotaA Fernández-Guasti
Mar 9, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B OlivierW Soudijn
Oct 3, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alain GobertMark J Millan
May 21, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mark J MillanGuillaume de Nanteuil
Jul 29, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mauricette BroccoMark J Millan
May 27, 2003·Human Psychopharmacology·Michael F O'Neil, Nicholas A Moore
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·B BertH Fink
Jun 15, 2004·European Journal of Pharmacology·J Adriaan BouwknechtRichard E Paylor
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronan DepoortereBernard Scatton
Sep 7, 2006·The Journal of Biological Chemistry·Jean-Martin BeaulieuMarc G Caron
Jan 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·Shigeyuki ChakiWilliam Thomsen
Feb 22, 2003·CNS Drug Reviews·Patricia A SeymourDavid W Schulz
Dec 14, 2011·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Edward H Hagen
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Eric W FishKlaus A Miczek

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