PMID: 1150575Jul 1, 1975

Reduction of hypoxic pulmonary vasoconstriction during trichloroethylene anesthesia

Journal of Applied Physiology
M K SykesJ B Hurtig


A double-lumen tube was inserted into the trachea of dogs anesthetized with intravenous pentobarbital (30-40 mg/kg). Blood flow/unit lung volume in each lung was measured with 133Xe. Both lungs were initially ventilated with oxygen and measurements of pulmonary blood flow, CO2 output, cardiac output, and blood gases were made. When nitrogen was administered to one lung blood flow was diverted to the opposite lung. The diversion of flow was reduced by the inhalation of 1% trichloroethylene but returned after withdrawal of the anesthetic. There were no significant changes in cardiac output. Changes in CO2 output and arterial Po2 were compatible with the xenon results. It is concluded that trichloroethylene may increase arterial hypoxemia by reducing vasoconstriction in hypoxic areas of lung.


May 12, 2004·Respiratory Physiology & Neurobiology·Tomonobu KoizumiXiaoqin Wang
Jan 1, 1979·Canadian Anaesthetists' Society Journal·A Fargas-Babjak, J B Forrest
Jul 1, 1985·Acta Anaesthesiologica Scandinavica·L BindslevI Gottlieb
Mar 31, 2007·High Altitude Medicine & Biology·Kenya WatanabeTadashige Shibamoto
Jan 1, 1985·Canadian Anaesthetists' Society Journal·Y D KimT E Macnamara
Sep 1, 1981·Canadian Anaesthetists' Society Journal·W H NobleJ A Fisher
Apr 3, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anis S BarakaChadi I Yaacoub

Related Concepts

Anesthesia Procedures
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