PMID: 3754206Feb 1, 1986Paper

Reduction of immunoreactive prostacyclin metabolite after paralysis in ventilated preterm infants

Early Human Development
J M RennieR W Cooke

Abstract

Levels of the stable metabolite of prostacyclin, 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were measured by radioimmunoassay during the first 48 hours of life in a group of 20 infants ventilated for the respiratory distress syndrome in whom a simultaneous record of respiratory activity was made. 6-Keto-PGF1 alpha was significantly lower when the infants were paralysed (P = 0.0004) than when they were breathing spontaneously. Elimination of the capacity for spontaneous respiration may reduce barotrauma and hence the stimulus for prostacyclin release from the lung.

References

Sep 1, 1984·Pediatric Research·R S Green, C W Leffler
Dec 1, 1984·Prostaglandins·C W LefflerR S Green
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J D Pickard
Aug 1, 1981·Prostaglandins·A EdlundA Wennmalm
Apr 1, 1982·Prostaglandins·I A BlairC T Dollery
Dec 1, 1982·Archives of Disease in Childhood·C M Taylor, C J Lote

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Citations

Mar 1, 1987·Indian Journal of Pediatrics·S Shankaran

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