Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury

Neuropharmacology
Pei-Pei ZhaiXia Li

Abstract

This study was designed to evaluate the neuroprotective effect of l-serine and the underlying mechanisms in mice after traumatic brain injury (TBI) induced using a weight drop model. The mice were intraperitoneally injected with l-serine 3 h after TBI and then injected twice each day for 7 days or until the end of the experiment. The neurological severity score, brain water content, lesion volume, and neurone loss were determined. The levels of TNF-α, IL-1β, IL-6, and IL-10 and the number of GFAP- and Iba-1-positive cells and activated caspase-3-positive neurones in the brain tissue ipsilateral to TBI were also measured. Simultaneously, the influences of l-serine on these variables were observed. In addition, the expression of glycine receptors and l-serine-induced currents were measured. We found l-serine treatment: 1) decreased the neurological deficit score, brain water content, lesion volume, and neurone loss; 2) inhibited activated caspase-3; and 3) reduced the levels of TNF-α, IL-1β and IL-6 and the number of GFAP- and Iba-1-positive cells. The effects of l-serine were antagonised by the administration of strychnine, an antagonist of glycine receptors. In addition, we found that glycine receptors were expressed mainly in ...Continue Reading

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Citations

Mar 7, 2018·Journal of Sports Sciences·Sarah Mc FieAlison V September
May 23, 2018·The Journal of Trauma and Acute Care Surgery·Yujin SutoJose L Pascual
Feb 23, 2020·Journal of Neuropathology and Experimental Neurology·David A DavisDeborah C Mash
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May 29, 2021·Scientific Reports·Kento KuritaTakayoshi Suganami
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Xiaoya ZhaoWenxia Xu

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