Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats

Acta Orthopaedica Scandinavica
Jörgen Astrand, P Aspenberg

Abstract

Bone resorption associated with prosthetic loosening can be reduced by giving bisphosphonates since they bind to bone surfaces and inactivate osteoclasts when bisphosphonate-containing bone is resorbed. During loosening, an increase in osteoclastic activity can be triggered by mechanical instability, fluid pressure or wear particles. We used a rat model in which a titanium surface can be made to slide over a bone surface and cause instability-induced bone resorption. 111 rats were operated on with a plate implant and treated with alendronate or clodronate injections in different doses or saline controls. After 4 weeks of osseointegration, the plate was moved during 2 weeks and the findings evaluated with histomorphometry. The percentage of persisting bone-metal contact and the soft tissue area at the interface were measured to estimate bone loss. Low or intermediate doses of the bisphosphonates increased the ash weight of untraumatized bone, but did not inhibit resorption at the unstable interface. Only rats treated with the highest doses of alendronate or clodronate had more bone-metal contact than controls. Instability-induced bone resorption therefore seems to be reduced by bisphosphonates, but higher doses are needed to obt...Continue Reading

References

Apr 3, 1998·Acta Orthopaedica Scandinavica·P Aspenberg, H van der Vis
Apr 7, 1999·Acta Orthopaedica Scandinavica·J Astrand, P Aspenberg
Nov 26, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H DaviJ F Thiercelin

❮ Previous
Next ❯

Citations

Jan 16, 2007·Der Orthopäde·C EberhardtA A Kurth
Feb 14, 2013·International Orthopaedics·Tomasz MazurkiewiczMagdalena Jaszek
May 15, 2013·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Łukasz MatuszewskiIwona Morawik
Apr 19, 2005·Expert Opinion on Investigational Drugs·James F Whitfield
Nov 25, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Christian EberhardtAndreas H Kurth
Jan 30, 2007·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Christian EberhardtAndreas H A Kurth
May 11, 2010·International Journal of Oral and Maxillofacial Surgery·J AbtahiP Aspenberg
May 19, 2009·Journal of Manipulative and Physiological Therapeutics·Charles N R HendersonJaeson T Fournier
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Regina LandesbergEthel Siris
Aug 12, 2009·Clinical Oral Implants Research·Carlos Madrid, Mariano Sanz
Jul 15, 2015·Der Orthopäde·R SkripitzA Roth
Feb 24, 2009·Acta Orthopaedica·Per Aspenberg
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jörgen Astrand, Per Aspenberg
Apr 3, 2003·Clinical Orthopaedics and Related Research·Jörgen AstrandPer Aspenberg
Nov 15, 2017·BMC Musculoskeletal Disorders·Thomas JakobsenOle Rahbek
Aug 15, 2006·Clinical Orthopaedics and Related Research·Gerjon HanninkPieter Buma
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Allen E GoodshipMelanie J Coathup
Dec 15, 2015·The Open Orthopaedics Journal·Thomas JakobsenOle Rahbek
Feb 10, 2006·Clinical Orthopaedics and Related Research·Christian EberhardtAndreas H Kurth
Mar 26, 2019·The Journal of Craniofacial Surgery·Manor YifatEithan Mijiritsky
Jan 22, 2005·Clinical Orthopaedics and Related Research·Takahiro MiyajiHideki Yoshikawa
Sep 10, 2015·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Yebin QianQiaojie Wang
Jun 8, 2004·Acta Orthopaedica Scandinavica·Henrik G AhlborgMagnus K Karlsson
Apr 6, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Arun S Shanbhag
Sep 21, 2007·International Journal of Immunopathology and Pharmacology·D BerardiG Perfetti
Aug 1, 2006·The Journal of Bone and Joint Surgery. British Volume·U Kesteris, P Aspenberg
May 2, 2009·The Journal of Bone and Joint Surgery. British Volume·F Agholme, P Aspenberg
Nov 13, 2020·Acta Biomaterialia·Mohammed MahriFaleh Tamimi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.