Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance

Diabetologia
Marie EriksenThure Krarup

Abstract

We evaluated the insulinotropic properties of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in healthy individuals at risk of developing type 2 diabetes before and after glucocorticoid-induced insulin resistance. Nineteen healthy, glucose tolerant, first-degree relatives of type 2 diabetic patients underwent OGTT and 7 mmol/l and 15 mmol/l glucose clamps with concomitant infusions of GLP-1, GIP or NaCl and a final infusion of arginine for determination of maximum beta cell capacity before and after treatment with dexamethasone. In addition, first-phase insulin responses were determined at 7 mmol/l and 15 mmol/l and second-phase insulin responses at 7 mmol/l. After dexamethasone treatment, all 19 participants had increased insulin resistance (HOMA-IR and insulin sensitivity index [M/I] values) and 2 h plasma glucose concentrations, while beta cell function indices generally increased according to the increased resistance. First-phase insulin responses induced by GLP-1 and GIP at 7 mmol/l and maximal beta cell secretory capacity did not differ before and after dexamethasone, while second-phase responses to 7 mmol/l and first-phase responses to 15 mmol/l glucose were reduced equally for bot...Continue Reading

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Citations

Mar 10, 2016·Hormone Molecular Biology and Clinical Investigation·Morgane RousselStéphane Dalle
Jun 13, 2017·Metabolic Syndrome and Related Disorders·Jens Juul HolstFilip Krag Knop
Nov 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Signe Tellerup NielsenKirsten Møller
Mar 27, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yvonne WinhoferLili Kazemi-Shirazi
Apr 7, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Anu Sharma, Adrian Vella
Oct 19, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·V A Gault
Jun 20, 2018·Frontiers in Endocrinology·Mattia BarbotCarla Scaroni
Jul 6, 2021·Frontiers in Endocrinology·Martin Brunel WhyteAnne M Umpleby
Aug 13, 2020·La Revue de médecine interne·M Bastin, F Andreelli

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