Reduction of Intracellular Chloride Concentration Promotes Foam Cell Formation

Circulation Journal : Official Journal of the Japanese Circulation Society
Qian-Qian WuSi-Jia Liang

Abstract

Previous work has demonstrated that the volume-regulated chloride channel is activated during foam cell formation, and inhibition of chloride movement prevents intracellular lipid accumulation. However, the mechanism explaining how chloride movement promotes foam cell formation is not clear. Foam cell formation was determined by Oil Red O staining. Western blotting and co-immunoprecipitation were used to examine protein expression and protein-protein interaction. [Cl(-)]iwas measured using 6-methoxy-N-ethylquinolinium iodide dye. The results showed that [Cl(-)]iwas decreased in monocytes/macrophages from patients with hypercholesterolemia and from apoE(-/-)mice fed with a high-fat diet. Lowering [Cl(-)]iupregulated scavenger receptor A (SR-A) expression, increased the binding and uptake of oxLDL, enhanced pro-inflammatory cytokine production and subsequently accelerated foam cell formation in macrophages from humans and mice. In addition, low Cl(-)solution stimulated the activation of JNK and p38 mitogen-activated protein kinases. Inhibition of JNK and p38 blocked Cl(-)reduced medium-induced SR-A expression and lipid accumulation. In contrast, reduction of [Cl(-)]ipromoted the interaction of SR-A with caveolin-1, thus facilitat...Continue Reading

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Citations

Nov 24, 2016·Journal of Cellular and Molecular Medicine·Bao-Dong TangRui-Ping Pang
Dec 21, 2016·Journal of Cellular Biochemistry·Mariángeles ClauzureTomás A Santa-Coloma
Aug 5, 2017·Acta Pharmacologica Sinica·Ya-Juan ZhangYong-Yuan Guan
Nov 7, 2019·American Journal of Physiology. Cell Physiology·Benjamin P LüscherShmuel Muallem
Jul 14, 2020·Bioscience, Biotechnology, and Biochemistry·Wenyuan DingFei Zheng
Jul 11, 2018·Cellular & Molecular Biology Letters·Jingjing LuJiewen Zhang

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