PMID: 6411484Jan 1, 1983Paper

Reduction of lipofuscin by centrophenoxine and chlorpromazine in the neurons of rat cerebral hemisphere in primary culture

Experimental Gerontology
R Ohtani, S Kawashima

Abstract

Cells from neonatal rat cerebral hemispheres were dispersed by trypsin and cultured for 32 days. Histochemical, fluorescence, and electron microscopic analyses demonstrated that lipofuscin pigments increased in neuronal and non-neuronal cells in primary culture according to the lapse of time. When centrophenoxine (10(-4) or 5 X 10(-4) M) or chlorpromazine (10(-6) or 10(-5) M) was added to the medium, the accumulation of lipofuscin pigments in neurons was significantly reduced. However, the effects of these agents were not detected in non-neuronal cells.

Citations

Mar 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·A B TatariunasV N Karnaukhov
Jun 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·V I PopovB L Allakhverdov
Mar 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·A B Tatariunas
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Uchibori, S Kawashima
Jan 17, 2012·Neurobiology of Aging·Sylvie Julien, Ulrich Schraermeyer
Apr 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·A B Tatariunas
Jul 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J H Dowson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here