Abstract
HIV infection is a major contributor to maternal mortality in resource-limited settings. The Drug Resource Enhancement Against AIDS and Malnutrition Programme has been promoting HAART use during pregnancy and postpartum for Prevention-of-mother-to-child-HIV transmission (PMTCT) irrespective of maternal CD4 cell counts since 2002. Records for all HIV+ pregnancies followed in Mozambique and Malawi from 6/2002 to 6/2010 were reviewed. The cohort was comprised by pregnancies where women were referred for PMTCT and started HAART during prenatal care (n = 8172, group 1) and pregnancies where women were referred on established HAART (n = 1978, group 2). 10,150 pregnancies were followed. Median (IQR) baseline values were age 26 years (IQR:23-30), CD4 count 392 cells/mm(3) (IQR:258-563), Viral Load log10 3.9 (IQR:3.2-4.4), BMI 23.4 (IQR:21.5-25.7), Hemoglobin 10.0 (IQR: 9.0-11.0). 101 maternal deaths (0.99%) occurred during pregnancy to 6 weeks postpartum: 87 (1.1%) in group 1 and 14 (0.7%) in group 2. Mortality was 1.3% in women with <than 350 CD4 cells/mm(3) and 0.7% in women with greater than 350 CD4s cells/mm(3) [OR = 1.9 (CL 1.3-2.9) p = 0.001]. Mortality was higher in patients with shorter antenatal HAART: 22/991 (2.2%) if less th...Continue Reading
References
Apr 3, 2004·AIDS·Simona FioreUNKNOWN European HIV in Obstetrics Group
Oct 4, 2005·Lancet·Ronald H GrayMaria J Wawer
Mar 15, 2006·Lancet·Paula BraitsteinUNKNOWN ART Cohort Collaboration (ART-CC) groups
Aug 2, 2007·Obstetrics and Gynecology·Judette LouisUNKNOWN Maternal-Fetal Medicine Units Network, National Institute of Child Health and Human Development
Mar 28, 2008·AIDS Research and Human Retroviruses·Maria Cristina MarazziLeonardo Palombi
Aug 2, 2008·Bulletin of the World Health Organization·Martin W G BrinkhofUNKNOWN ART-LINC, IeDEA
May 23, 2009·American Journal of Clinical Pathology·Marco VitoriaKevin M De Cock
Jul 23, 2009·Obstetrics and Gynecology·Vivian BlackMatthew F Chersich
Sep 15, 2009·BMC Medical Informatics and Decision Making·Andrea NucitaLeonardo Palombi
Jan 15, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·John GrangeAlimuddin Zumla
Jun 24, 2010·Lancet·Quarraisha Abdool-KarimIsabelle de Zoysa
Feb 23, 2011·Memórias do Instituto Oswaldo Cruz·Victor H MeloJennifer S Read
Jun 16, 2011·AIDS·Maria C MarazziGiuseppe Liotta
May 18, 2012·Journal of Pregnancy·Oliver EzechiJosaphat Byamugisha
Citations
Dec 2, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tamil KendallMary Nell Wegner
Jan 5, 2017·AIDS Patient Care and STDs·Rebecca Marie ZashRoger L Shapiro
Oct 11, 2017·Expert Review of Clinical Pharmacology·Robert Pope, Angela Kashuba
Feb 26, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Batya ElulConstantin T Yiannoutsos
Nov 28, 2017·Journal of the International AIDS Society·Coceka N MnyaniJames A McIntyre
Oct 11, 2014·PloS One·Christopher J ColvinKaren Fogg
Nov 6, 2014·PloS One·Ian HodgsonKaren P Fogg
Oct 8, 2017·Malaria Journal·Sung Eun ChoiEran Bendavid
Mar 27, 2020·Research and Practice in Thrombosis and Haemostasis·Lian LancasterAnnette von Drygalski
Nov 11, 2020·PloS One·Fausto CiccacciMaria Cristina Marazzi
Jan 5, 2021·BMC Infectious Diseases·Animut AlebelDavid Sibbritt
Jan 26, 2021·JMIR Research Protocols·Stefano OrlandoLeonardo Palombi