Reduction of methionine selenoxide to selenomethionine by glutathione

Archives of Biochemistry and Biophysics
A AssmannH Sies

Abstract

Selenomethionine, an amino acid occurring in proteins in place of methionine, reacts efficiently with oxidants, e.g., peroxynitrite, a biological oxidant generated in inflammatory states, to produce the oxidation product, methionine selenoxide. The present work describes the rapid and efficient reduction of the selenoxide to selenomethionine by glutathione in a stoichiometric reaction utilizing two equivalents of thiol. This nonenzymatic reaction establishes a defense line against peroxynitrite or other oxidants by selenomethionine residues in proteins, maintained by the ubiquitous thiol, glutathione.

References

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Citations

Apr 17, 2010·Amino Acids·Robert J Hondal, Erik L Ruggles
Dec 19, 2006·Chemical Research in Toxicology·Renee J KrauseAdnan A Elfarra
Sep 23, 2009·Antioxidants & Redox Signaling·Markus SeleniusMikael Björnstedt
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Jun 27, 2019·Environmental Science and Pollution Research International·Yao YuHua-Fen Li
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May 23, 2020·Free Radical Biology & Medicine·Luke CarrollMichael J Davies
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Aug 6, 2000·Free Radical Biology & Medicine·H Sies, G E Arteel
Apr 26, 2000·Biochimica Et Biophysica Acta·X YangR F Burk

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