PMID: 37234Jul 1, 1979

Reduction of methionine sulfoxide to methionine by Escherichia coli

Journal of Bacteriology
S I EjiriN Brot


L-Methionine-dl-sulfoxide can support the growth of an Escherichia coli methionine auxotroph, suggesting the presence of an enzyme(s) capable of reducing the sulfoxide to methionine. This was verified by showing that a cell-free extract of E. coli catalyzes the conversion of methionine sulfoxide to methionine. This reaction required reduced nicotinamide adenine dinucleotide phosphate and a generating system for this compound. The specific activity of the enzyme increased during logarithmic growth and was maximal when the culture attained a density of about 10(9) cells per ml.


May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zhidong LinW Todd Lowther
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Adrian DrazicJeannette Winter
Nov 9, 2002·European Journal of Biochemistry·Sung-Jong Jeon, Kazuhiko Ishikawa
Apr 14, 2007·Current Genetics·Stéphane D LemaireEmmanuelle Issakidis-Bourguet
Nov 4, 2010·The Biochemical Journal·Panchanan MaitiGal Bitan
Mar 15, 1984·European Journal of Biochemistry·S RapoportG Hausdorf
Feb 27, 2001·The Journal of General Physiology·X D TangT Hoshi
Jan 10, 1998·The Journal of Biological Chemistry·A Miranda-VizueteG Spyrou
Feb 24, 2001·Antioxidants & Redox Signaling·A Miranda-VizueteG Spyrou
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