Reduction of mortality and lymphadenopathy in MRL-lpr/lpr mice treated with nonmitogenic anti-CD3 monoclonal antibody

Arthritis and Rheumatism
M HenricksonR Hirsch


To evaluate the therapeutic efficacy of nonmitogenic anti-CD3 monoclonal antibody (MAb) in a preexisting autoaggressive response, using the MRL-lpr/lpr (MRL/l) murine model of autoimmune disease. Female MRL/l mice, 8-10 weeks of age, were treated with nonmitogenic anti-CD3 MAb or phosphate buffered saline and effects on mortality, lymphadenopathy, T cell phenotypes, anti-DNA titers, and total IgG titers were measured. Nonmitogenic anti-CD3 MAb treatment resulted in a dramatic reduction in lymphadenopathy and mortality, as well as an early reduction in alpha/beta+, CD4-, CD8-, Thy+, B220+ (double-negative) lymph node cells. No significant effects on anti-DNA or IgG titers were observed. No morbidity was observed following administration of nonmitogenic anti-CD3 MAb. A short course of treatment with nonmitogenic anti-CD3 MAb can suppress preexisting autoimmune responses without inducing the cytokine-mediated toxicity characteristic of mitogenic forms of anti-CD3 MAb. The use of nonmitogenic anti-CD3 MAb may be efficacious in the clinical setting for the treatment of T cell-mediated autoimmune disorders.


Dec 1, 1991·The Journal of Experimental Medicine·C KimA Ochi
Oct 1, 1990·The Journal of Experimental Medicine·Y Kawabe, A Ochi
Feb 1, 1991·Arthritis and Rheumatism·G HorneffJ R Kalden
Dec 1, 1990·The Journal of Experimental Medicine·C AnasettiP J Martin
Jun 17, 1989·Lancet·R HirschJ A Bluestone
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O LeoJ A Bluestone
Apr 1, 1986·The Journal of Experimental Medicine·J SprentR Korngold
Jan 1, 1985·Advances in Immunology·A N Theofilopoulos, F J Dixon
Feb 1, 1985·The Journal of Experimental Medicine·D Wofsy, W E Seaman
Sep 1, 1985·The Journal of Experimental Medicine·G E RangesS M Cooper
Dec 1, 1984·Transplantation·J R ThistlethwaiteP S Russell
Nov 1, 1981·The Journal of Experimental Medicine·D WofsyN Talal

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