Nov 1, 1981

Reduction of myocardial infarct size in swine: a comparative study of intraaortic balloon pumping and transapical left ventricular bypass

The Annals of Thoracic Surgery
Y TakanashiR L Replogle

Abstract

This study compared intraaortic balloon pumping (IABP) and transapical left ventricular (LV) bypass for their effectiveness in reducing infarct size in swine. In 28 pigs (25.4 +/- 4.7 kg) the left anterior descending coronary artery was ligated distal to the first diagonal branch. Nine animals served as controls. Nine animals were treated with IABP and the remaining 10, with transapical bypass. Ten animals-3 control, 3 IABP, and 4 transapical bypass--died prior to completion of the study, thereby resulting in 6 animals in each group. Both assist devices were begun 45 minutes after coronary ligation, this being as rapid as mechanical intervention could be accomplished in the patient after infarction. With transapical LV bypass, 70 to 100% bypass was accomplished and the LV systolic pressure remained in the range between mean aortic pressure and 30 mm Hg less than that. All animals were killed after 24 hours. The hearts were excised and stained with nitroblue tetrazolium, and infarct size was quantitated in grams of infarct per 100 gm of LV and septal mass. After 24 hours the mean aortic pressure was 73 +/- 12 mm Hg in controls, 105 +/- 20 mm Hg in animals with IABP (p less than 0.01), and 91 +/- 13 mm Hg in those with transapica...Continue Reading

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Mentioned in this Paper

Diastolic Blood Pressure
Myocardium
Myocardial Infarction
Mean Aortic Pressure
Intra-Aortic Balloon Pumping
Heart
Extracorporeal Circulation
Heart Ventricle
Cardiac Output
PIGS gene

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