Nov 1, 1981

Reduction of myocardial infarct size in swine: a comparative study of intraaortic balloon pumping and transapical left ventricular bypass

The Annals of Thoracic Surgery
Y TakanashiR L Replogle


This study compared intraaortic balloon pumping (IABP) and transapical left ventricular (LV) bypass for their effectiveness in reducing infarct size in swine. In 28 pigs (25.4 +/- 4.7 kg) the left anterior descending coronary artery was ligated distal to the first diagonal branch. Nine animals served as controls. Nine animals were treated with IABP and the remaining 10, with transapical bypass. Ten animals-3 control, 3 IABP, and 4 transapical bypass--died prior to completion of the study, thereby resulting in 6 animals in each group. Both assist devices were begun 45 minutes after coronary ligation, this being as rapid as mechanical intervention could be accomplished in the patient after infarction. With transapical LV bypass, 70 to 100% bypass was accomplished and the LV systolic pressure remained in the range between mean aortic pressure and 30 mm Hg less than that. All animals were killed after 24 hours. The hearts were excised and stained with nitroblue tetrazolium, and infarct size was quantitated in grams of infarct per 100 gm of LV and septal mass. After 24 hours the mean aortic pressure was 73 +/- 12 mm Hg in controls, 105 +/- 20 mm Hg in animals with IABP (p less than 0.01), and 91 +/- 13 mm Hg in those with transapica...Continue Reading

  • References12
  • Citations5

Mentioned in this Paper

Diastolic Blood Pressure
Myocardial Infarction
Mean Aortic Pressure
Intra-Aortic Balloon Pumping
Extracorporeal Circulation
Heart Ventricle
Cardiac Output
PIGS gene

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.