PMID: 7050044Mar 1, 1982

Reduction of nitroimidazoles in model chemical and biological systems

International Journal of Radiation Oncology, Biology, Physics
P WardmanM E Watts

Abstract

Some chemical and biological properties of intermediates obtained during reduction of nitroimidazoles are discussed. These include: rate data for the decay of the nitro radical-anion, stoichiometry and absorption spectra for reduction via the radical-anion or using dithionite, stoichiometry with other reducing agents, and rate of reduction by xanthine/xanthine oxidase. Increased radiosensitization by misonidazole is seen upon prolonged pre-irradiation incubation using E. coli, enabling demonstration that a freely-diffusable metabolite is responsible for this effect. Preliminary experiments designed to extend studies of the radiobiological properties of extracellularly-added metabolites to mammalian cells and the use of liver perfusion to generate metabolites are described.

References

Feb 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I R FlockhartT R Marten
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·D G Lindmark, M Müller
Dec 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R L WillsonR M Ings
Nov 1, 1970·Journal of General Microbiology·D I Edwards, G E Mathison
Apr 15, 1981·Biochemical Pharmacology·P D JosephyL D Skarsgard
Jan 1, 1980·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A Clarke, A Clarke

Citations

Jan 1, 1985·Molecular and Biochemical Parasitology·N YarlettM Müller
Jan 1, 1988·Drug Metabolism Reviews·G L Kedderis, G T Miwa
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·D I EdwardsA Zahoor
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·P WardmanM R Stratford
May 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·Y HenryB Hickel
Nov 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T KagiyaT Wada

Related Concepts

Drug Stability
Alkalescens-Dispar Group
Liver
Nitroimidazoles
Oxidation-Reduction
Radiation-Sensitizing Effect

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