Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Neil J Grey, George A Perdrizet

Abstract

To investigate whether hyperglycemia in glucose-intolerant patients without diabetes could lead to increased nosocomial infections in the surgical intensive-care unit (ICU). A prospective, randomized, controlled clinical trial was conducted in the surgical ICU of a large teaching hospital in Hartford, Connecticut. Adult patients admitted to a 12-bed surgical ICU requiring treatment of hyperglycemia (glucose values > or = 140 mg/dL) were randomly assigned to receive standard insulin therapy (target glucose range, 180 to 220 mg/dL) or strict insulin therapy (target glucose range, 80 to 120 mg/dL) throughout their ICU stay. Demographic data, comorbidities, and confounding variables were analyzed. Outcome measures included mean daily serum glucose values, mean daily insulin doses, and number of nosocomial infections during the ICU stay. The study was completed by 61 critically ill surgical patients (27 in the standard glucose control group and 34 in the strict glucose control group). A significant reduction (P<0.001) in mean daily glucose level was achieved in the strict glycemic control group (125 +/- 36 mg/dL) in comparison with the standard glycemic control group (179 +/- 61 mg/dL). Furthermore, a significant reduction (P<0.05) ...Continue Reading

References

Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·P J HennesseyR J Andrassy
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Mar 25, 1971·The New England Journal of Medicine·A Mowat, J Baum
Mar 1, 1982·The American Journal of Medicine·E J RayfieldH Smith
Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·J J PomposelliB R Bistrian
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W E TrickW R Jarvis
Jun 22, 2000·The Journal of Hospital Infection·M H Wilcox, J Dave

❮ Previous
Next ❯

Citations

Nov 24, 2007·Der Anaesthesist·B EllgerG Van den Berghe
Nov 26, 2008·Internal and Emergency Medicine·Chiara LazzeriGian Franco Gensini
Nov 17, 2011·Current Diabetes Reports·Ariana Pichardo-Lowden, Robert A Gabbay
Jan 3, 2006·Diabetes Technology & Therapeutics·Nathan LongFrancis Moussy
Aug 31, 2006·Diabetes Technology & Therapeutics·Susan S BraithwaiteEdmund J Rutherford
Oct 19, 2011·Surgical Infections·Addison K MayBryan R Collier
Aug 19, 2006·Critical Care Medicine·Matthias TurinaHiram C Polk
Sep 22, 2007·Critical Care Medicine·Ilse VanhorebeekGreet Van den Berghe
Jun 15, 2006·Annals of Surgery·Matthias TurinaHiram C Polk
Jul 17, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ricki Y FramDavid N Herndon
Nov 21, 2008·Critical Care Medicine·Ingeborg van den Heuvel, Björn Ellger
Dec 31, 2008·Critical Care Medicine·Sean M BagshawUNKNOWN Australia New Zealand Intensive Care Society Database Management Committee
Jun 18, 2009·Critical Care Medicine·Shyoko Honiden, Michelle N Gong
Nov 20, 2009·Critical Care Medicine·Rattan Juneja, Timothy Meakem
Sep 23, 2009·Critical Care Medicine·Gerd G GauglitzMarc G Jeschke
Dec 8, 2010·Annals of Surgery·Joseph T KingRonnie A Rosenthal
Nov 14, 2008·Southern Medical Journal·Muge Aydogdu, Gul Gursel
Aug 19, 2007·The Journal of Trauma·R Shayn MartinMichael C Chang
Feb 28, 2008·Critical Care : the Official Journal of the Critical Care Forum·Tom Van HerpeGreet Van den Berghe
Aug 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Regula MeierJohn F Stover
Jun 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawUNKNOWN ANZICS CORE Management Committee
Nov 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jan O FriedrichNeill K J Adhikari
Mar 26, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Donald E G GriesdaleDaniel Talmor
Dec 31, 2010·Vascular Health and Risk Management·Samer Ellahham
Oct 12, 2012·International Journal of Medical Sciences·Rolf HinzmannCam Tuan Tran
Jul 4, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·C Ichai
Aug 27, 2014·The Nursing Clinics of North America·Florence AgosDeborah Bransford
Dec 3, 2014·The Surgical Clinics of North America·Mohamed F Osman, Reza Askari
May 15, 2012·Minerva anestesiologica·D Andel, L P Kamolz
Feb 22, 2016·The American Journal of the Medical Sciences·Nagham JafarKenneth Nugent
Dec 25, 2015·Current Diabetes Reports·Bithika M ThompsonCurtiss B Cook
Sep 7, 2013·Journal of Clinical Anesthesia·Basem B Abdelmalak, M Cecilia Lansang
Oct 31, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·J-V SchaalS Mérat
Oct 20, 2012·Molecular Aspects of Medicine·Jennifer E Snyder-Cappione, Barbara S Nikolajczyk
Jul 13, 2007·Chest·Ilse VanhorebeekGreet Van den Berghe
May 12, 2012·Endocrinology and Metabolism Clinics of North America·Marie E McDonnell, Guillermo E Umpierrez
Oct 29, 2010·Journal of the American College of Surgeons·Bryce W MurrayThomas Anthony
Jan 30, 2010·Best Practice & Research. Clinical Anaesthesiology·Ilse Vanhorebeek, Lies Langouche
Dec 1, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Thomas F Floyd, Jiri Horak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.