Reduction of pegaptanib loss during intravitreal delivery using an oblique injection technique

Eye
L Lopez-GuajardoM A Teus

Abstract

To develop an injection technique that reduces drug loss occurring due to reflux and consequent subconjunctival bleb formation after standard intravitreal pegaptanib injection. Prospective interventional case series report. The 27-gauge needle is inserted obliquely via pars plana to create a valved wound. The rate of subconjunctival bleb formation is evaluated performing ultrasound biomicroscopy, (1/2)h after intravitreal drug delivery comparing standard (straight)with this new described injection technique (oblique) using Fisher's exact test. Eyes on which oblique injection technique was performed developed significantly less subconjunctival bleb than those treated with the standard technique. The rate of injection-related complications (retinal detachment, vitreous haemorrhage, traumatic cataract, and endophthalmitis) in our small series was similar between both groups. The use of this technique can result in reduced drug loss after intravitreal pegaptanib injection. Larger studies are needed to determine if the rate of complications associated with intravitreal injections, especially endophthalmitis, is lowered with this technique.

References

Jan 1, 1991·Journal of Cataract and Refractive Surgery·P H ErnestK T Lavery
Oct 1, 1996·Archives of Ophthalmology·J C Chen
Oct 16, 2004·Retina·Lloyd P AielloMichael T Trese
Oct 20, 2004·Retina·Rama D JagerEmmett T Cunningham
Nov 9, 2004·American Journal of Ophthalmology·Itamar YeshurunElisha Bartov
Jun 13, 2006·American Journal of Ophthalmology·Lorenzo López-GuajardoMiguel Angel Teus-Guezala
Oct 24, 2006·American Journal of Ophthalmology·Hiroyuki ShimadaTakayuki Hattori
May 26, 2007·American Journal of Ophthalmology·Eduardo B RodriguesMichel E Farah

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Citations

Feb 15, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eduardo B RodriguesMichel E Farah
Nov 17, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Abdullah ÖzkayaAhmet Demirok
Sep 26, 2009·Retina·Jean-Pierre HubschmanSteven D Schwartz
Feb 4, 2014·Expert Review of Clinical Pharmacology·Michael W Stewart
Nov 3, 2011·Seminars in Ophthalmology·Muhammad Usman SaeedDavid Clark
Dec 21, 2010·American Journal of Ophthalmology·Amy E Green-SimmsSophie J Bakri
Apr 8, 2011·Seminars in Ophthalmology·Muhammad Usman SaeedDavid Clark
Apr 8, 2014·European Journal of Ophthalmology·Pablo Carnota-MéndezJosé Antonio Saavedra-Pazos
Apr 21, 2020·Progress in Retinal and Eye Research·Gustavo Barreto MeloEduardo Büchele Rodrigues

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