Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study.

Frontiers in Immunology
Chao ZhouYue Ren

Abstract

Objective: To investigate the frequencies and numbers of invariant natural killer T (iNKT) cells and γδT cells in the peripheral blood of patients with the Parkinson's disease (PD), and to examine their association with the PD severity. Methods: Peripheral blood samples from 47 PD patients (PD group) and 47 age-matched healthy control subjects (HC group) were collected. The frequencies and the absolute cell numbers were analyzed by flow cytometry. Mann-Whitney U-test was used to test the difference between two groups, where P < 0.05 was considered as significant. An ordered probit regression method was used to examine the association of the iNKT and γδT cells with severity of PD. Results: Patients in the PD group showed significantly lower frequencies (0.039 vs. 0.139%; P = 0) and cell counts (308/mL vs. 1,371/mL; P = 0) of iNKT cells compared to the HC group. Moreover, the percentages and absolute numbers of γδT cells were significantly decreased in the PD group compared to the HC group (3.69 vs. 7.95% and 30/μL vs. 66/μL; P = 0). The iNKT cells were significantly reduced in PD patients with higher Unified Parkinson's Disease Rating Scale (UPDRS) scores or cognitive decline. Conclusions: Cell frequencies and absolute numbers o...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K SelmajC S Raine
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jan 4, 2001·Journal of Neuroimmunology·J BasE Buendia
Feb 13, 2003·International Immunology·Manabu ArakiTakashi Yamamura
Sep 13, 2005·Parkinsonism & Related Disorders·Yasuhiko BabaTatsuo Yamada
Sep 27, 2005·Neurobiology of Disease·Alexander GerhardDavid J Brooks
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Dec 24, 2008·The Journal of Clinical Investigation·Vanessa BrochardStéphane Hunot
Sep 21, 2011·Geriatrics & Gerontology International·Fumitoshi NiwaJiro Imanishi
Jun 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura DenneyLing-Pei Ho
Aug 23, 2012·Journal of Neuroimmunology·Claire H StevensGlenda M Halliday
Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica A Hutter SaundersHoward E Gendelman
Nov 28, 2013·Journal of Parkinson's Disease·George T KannarkatMalú G Tansey
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Mar 22, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Caroline H Williams-GrayUNKNOWN ICICLE-PD study group
Jul 2, 2016·Journal of Neuroinflammation·Annika SommerIryna Prots
Mar 10, 2018·Cellular and Molecular Life Sciences : CMLS·Christian PetersDaniela Wesch
Jan 9, 2019·Frontiers in Neurology·Jens B SchröderTobias Warnecke

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Citations

Apr 20, 2021·Frontiers in Immunology·Yunxuan LiXun Zeng

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS
FlowJo

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