Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease

The New England Journal of Medicine
M R MalinowB M Upson

Abstract

The Food and Drug Administration (FDA) has recommended that cereal-grain products be fortified with folic acid to prevent congenital neural-tube defects. Since folic acid supplementation reduces levels of plasma homocyst(e)ine, or plasma total homocysteine, which are frequently elevated in arterial occlusive disease, we hypothesized that folic acid fortification might reduce plasma homocyst(e)ine levels. To test this hypothesis, we assessed the effects of breakfast cereals fortified with three levels of folic acid, and also containing the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blind, placebo-controlled, crossover trial in 75 men and women with coronary artery disease. Plasma folic acid increased and plasma homocyst(e)ine decreased proportionately with the folic acid content of the breakfast cereal. Cereal providing 127 microg of folic acid daily, approximating the increased daily intake that may result from the FDA's enrichment policy, increased plasma folic acid by 31 percent (P=0.045) but decreased plasma homocyst(e)ine by only 3.7 percent (P= 0.24). However, cereals providing 499 and 665 microg of folic acid daily increased plasma folic acid by 64.8 percent (P<0.001) and 105.7 percent ...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Jan 1, 1992·Annual Review of Nutrition·S S KangM R Malinow
Jul 1, 1988·Metabolism: Clinical and Experimental·S S KangG Grcevich
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Feb 2, 1995·The New England Journal of Medicine·M J Stampfer, M R Malinow
Apr 1, 1995·Journal of Internal Medicine·F LandgrenL Brattström
Oct 1, 1994·The Journal of Nutrition·J B UbbinkH C Potgieter
Dec 1, 1994·Metabolism: Clinical and Experimental·R P Steegers-TheunissenT K Eskes
Mar 1, 1996·Journal of the American College of Cardiology·E L MayerK Robinson
Apr 1, 1996·The Journal of Nutrition·L Brattström
Jan 1, 1996·Kidney International·A G BostomI H Rosenberg
Jun 1, 1996·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·R Pernice, K Lys
Dec 18, 1996·JAMA : the Journal of the American Medical Association·K L TuckerJ Selhub
Feb 1, 1997·Current Opinion in Lipidology·P B Duell, M R Malinow
Jun 1, 1997·The American Journal of Clinical Nutrition·G P Oakley
Jul 24, 1997·The New England Journal of Medicine·O NygårdS E Vollset
Aug 1, 1997·Obstetrics and Gynecology·A RajkovicM R Malinow

❮ Previous
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Citations

Feb 24, 2001·Clinical Cardiology·A U Chai, J Abrams
Oct 3, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K Pietrzik
Nov 13, 2008·Cytotechnology·Joslynn G Affleck, Virginia K Walker
Feb 12, 2002·Lipids·M Cattaneo
May 24, 2003·Current Diabetes Reports·Pierre Theuma, Vivian A Fonseca
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·N S Key
Jan 30, 2004·The American Journal of Medicine·Jeffrey L AndersonJoseph B Muhlestein
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Cheryl D Bushnell, Larry B Goldstein
Nov 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Deodato AssanelliFrancesco Visioli
Jun 11, 1999·Journal of the American Dietetic Association·S G Affenito, J Kerstetter
Sep 5, 2002·The American Journal of Cardiology·Jeffrey L AndersonUNKNOWN Intermountain Heart Collaborative Study Group
Jun 16, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·S CalişkanB Onvural
Feb 28, 2002·AIDS Treatment News
Oct 16, 1999·Fertility and Sterility·M M Seibel
Sep 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S E MinerH J Ross
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Francesco ParisiGlauco Catena
Dec 9, 2000·Biochimica Et Biophysica Acta·D J McNamara
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Véronique DucrosUNKNOWN SFBC Working group on homocysteine. French Society for Clinical Biology
Jul 16, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael RychlikIrmgard Bitsch
Sep 6, 2008·Nature Protocols·Yuying Tan, Robert M Hoffman
Aug 10, 2000·Clinical and Laboratory Haematology·M Makris
Feb 26, 2000·Journal of Internal Medicine·H Bar-OnG Friedman
May 15, 2001·Journal of Internal Medicine·P KnektA Reunanen
Sep 1, 2000·Asia Pacific Journal of Clinical Nutrition·P R Howe
Apr 16, 1998·The New England Journal of Medicine·G P Oakley
Aug 15, 1998·The New England Journal of Medicine·J C DeutschJ F Kolhouse
May 13, 1999·The New England Journal of Medicine·P F JacquesI H Rosenberg
Oct 10, 2001·The British Journal of Nutrition·P J MoynihanA J Adamson
Jan 31, 2006·The British Journal of Nutrition·Cornelia M WitthöftJack R Dainty

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