Reduction of platelet serotonin content in depressed patients treated with either paroxetine or desipramine

The International Journal of Neuropsychopharmacology
Martin A. JavorsAlan Frazer

Abstract

Drugs thought to be selective inhibitors of either the uptake of serotonin (5-HT) or norepinephrine (NE) are known to be effective antidepressants. In general, a relative selectivity for NE vs. 5-HT uptake inhibition greater than 50-fold in vitro is thought to be sufficient to maintain such selectivity in vivo. To explore this issue, we carried out a study in which depressed patients were treated with either the selective serotonin reuptake inhibitor (SSRI) paroxetine or the selective norepinephrine reuptake inhibitor (SNRI) desipramine. Patients were treated with either drug or placebo for 6 wk. Drug levels in plasma and platelet 5-HT content were measured 12 times during the treatment period using HPLC procedures. Both drug treatments caused a significant reduction of platelet 5-HT content. Paroxetine reduced platelet 5-HT content to approx. 1% of pretreatment levels (n = 3). The inhibition of 5-HT uptake by paroxetine appeared to be immediate and complete. Desipramine reduced platelet 5-HT content to 38.7+/-6.2 % of pretreatment levels (n = 5) at a mean plasma level of 195 ng/ml. The percent reduction of platelet 5-HT content after 6 wk of drug treatment was proportional to the steady state plasma level of desipramine. The I...Continue Reading

Citations

Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dorotea Mück-SelerAlma Mihaljević-Peles
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nela PivacAlma Mihaljević-Peles
Sep 28, 2002·Epilepsy Research·Danka Pericić, Dubravka Svob
Jan 6, 2007·The Tohoku Journal of Experimental Medicine·Ahmet Mesut OnatMeral Calgüneri
Dec 23, 2015·Journal of Psychiatric Research·Deborah R KimKatherine L Wisner
Sep 1, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael DallJesper Hallas
Oct 24, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bankole A JohnsonJennie Z Ma
Apr 10, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Kristian Lundsgaard KraglundGrethe Andersen
Apr 14, 2006·Basic & Clinical Pharmacology & Toxicology·Francisco J de AbajoMariano Madurga
Nov 30, 2004·General Hospital Psychiatry·Asli KurneKazim M Yazici
Sep 2, 2006·The American Journal of Medicine·Yuhong YuanRichard H Hunt
Aug 9, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Joel J NapeñasPeter B Lockhart
May 13, 2015·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Fatih KayhanFaruk Uguz
Mar 30, 2018·International Journal of Molecular Sciences·Alia SadiqSaeid Amini-Nik
Aug 22, 2017·Expert Review of Clinical Pharmacology·Claudia Stöllberger
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin M KatzAlan Frazer
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Jordan KharofaDaniel Woo
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dan AtarVictor L Serebruany
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Raymond G Schlienger, Christoph R Meier
Apr 4, 2014·The Cochrane Database of Systematic Reviews·Marianna PurgatoCorrado Barbui
May 11, 2011·Scandinavian Journal of Gastroenterology·Michael DallJesper Hallas
Nov 3, 2016·Journal of Clinical Psychopharmacology·Steven P Roose, Bret R Rutherford
Apr 19, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Janice MaJohn Sampalis
Oct 23, 2019·Heart, Lung & Circulation·George MawardiBrian A Houston
May 5, 2007·Journal of Psychosocial Nursing and Mental Health Services·Roy R ReevesSera K Cox
Mar 27, 2021·The European Journal of Neuroscience·Jasmin ObermannsBarbara Emons
May 8, 2021·Frontiers in Pharmacology·Vikas P SukhatmeVidula V Sukhatme
Sep 28, 2021·International Journal of Immunopathology and Pharmacology·Paul E MarikPierre Kory

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