PMID: 8587698Jul 1, 1995Paper

Reduction of post-traumatic intracranial hypertension by hypertonic/hyperoncotic saline/dextran and hypertonic mannitol

Neurosurgery
S BergerA Baethmann

Abstract

Cerebral injury is seen in one of three patients with multiple traumas; thus efficient shock treatment is a most important measure against the development of secondary brain damage. Small-volume resuscitation in severe hemorrhagic shock by hypertonic/hyperoncotic saline/dextran has been shown to instantaneously normalize cardiac output and to raise systemic blood pressure. In this study, the fluid regimen was compared with hypertonic mannitol to investigate their therapeutic efficacy in intracranial hypertension. The experiments were performed in rabbits subjected to a focal lesion of the brain to induce acute, vasogenic brain edema. The resulting intracranial hypertension was enhanced in a standard manner by inflation of an epidural balloon until an intracranial pressure (ICP) of 17 mm Hg was obtained. Intravenous administration of either 7.2% saline/10% dextran-60 or of 20% mannitol rapidly decreased the elevated ICP. After the first injection, ICP lowering was maintained longer by the mannitol than by the hypertonic saline/dextran, whereas no differences in duration of ICP lowering were found when the infusions of these solutions were repeated. The systemic blood pressure increased after injection of the saline/dextran solut...Continue Reading

References

Aug 4, 1978·JAMA : the Journal of the American Medical Association·J D MillerD P Becker
Jan 1, 1992·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·L SchürerA Baethmann
Dec 1, 1992·Journal of Neurosurgery·J PiekM A Foulkes
Oct 1, 1992·Journal of Neurosurgery·A M Kaufmann, E R Cardoso
Jan 1, 1991·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A Chávez-NegreteR Argüero
Oct 1, 1990·The Journal of Trauma·S M KaweskiR W Virgilio
Jan 1, 1989·Resuscitation·K Messmer, U Kreimeier
Sep 1, 1989·The Journal of Trauma·T A GennarelliW M Alves
Jul 1, 1986·Journal of Neurosurgery·F Nath, S Galbraith
Jan 1, 1985·The Journal of Trauma·J P SmithC F Frey
Dec 1, 1985·The Journal of Surgical Research·G J SmithJ W Holcroft
Mar 1, 1981·Journal of Neurosurgery·J D MillerD P Becker
Apr 1, 1964·The Journal of Clinical Investigation·R W WINTERSM VEROSKY

❮ Previous
Next ❯

Citations

Jan 1, 1997·Acta neurochirurgica·C OnalM Y Kaynar
Feb 14, 2012·Neurocritical Care·Karen G HirschRomergryko G Geocadin
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Arlan L Rosenbloom
Oct 17, 1998·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·S Talbert, P Talbert
May 22, 2007·Journal of Neurotrauma·Susan L BrattonDavid W Wright
Jan 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M Stanton-Hicks, J Salamon
Oct 8, 2003·Critical Care Medicine·A HeimannO Kempski
Mar 15, 2006·The Neurologist·Alejandro A Rabinstein
Sep 25, 2008·Critical Care Medicine·Justin F Fraser, Roger Härtl
Jan 6, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Benjamin S ElkinBarclay Morrison
Sep 1, 2004·Neurosurgery·Stefan ZausingerRobert Schmid-Elsaesser
Aug 12, 2005·Neurosurgery·Alfred T OgdenE Sander Connolly
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Arlan L Rosenbloom
Jul 7, 2007·Neurosurgical Focus·Ahmed Raslan, Anish Bhardwaj
Mar 25, 2009·Neurological Research·Joacil Carlos da SilvaHildo Rocha Cirne de Azevedo Filho
Jun 11, 2014·Journal of Neurotrauma·Celeste DiasMarek Czosnyka
Aug 1, 2008·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Jeffrey E CatramboneAllen Maniker
Feb 14, 2009·The American Journal of the Medical Sciences·Chia-Chyuan LiuHung-Jung Lin
Dec 26, 2012·Advances in Chronic Kidney Disease·Jerry Yee
Aug 10, 2012·Advances in Surgery·Eileen M Bulger, David B Hoyt
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Michael BauerKonrad Reinhart
Aug 28, 2010·Critical Care Medicine·Shelly D Timmons
Nov 23, 2006·The Surgical Clinics of North America·Alberto Garcia
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Orville D PalmerCarolyn Pinnock
May 9, 2008·Emergency Medicine Australasia : EMA·Colin J Banks, Jeremy S Furyk
Sep 3, 2010·International Journal of Imaging Systems and Technology·Victor S LelyveldAlan Jasanoff
Jul 25, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·L PetitF Sztark
Dec 14, 2005·Journal of the Neurological Sciences·Christian BermuellerStefan Zausinger
Dec 27, 2005·Journal of the American College of Surgeons·Tim P NichollsAlexis B C Dang
Aug 9, 2002·Anesthesiology Clinics of North America·Concezione Tommasino
Feb 26, 2004·Critical Care Clinics·Randall M Chesnut
Mar 3, 2015·Annals of the New York Academy of Sciences·Halinder S Mangat, Roger Härtl
Feb 18, 2014·Irish Journal of Medical Science·E H MajorB Mullan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.