Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel

Fertility and Sterility
R E LeachM P Diamond

Abstract

To assess the efficacy of a bioabsorbable gel for reducing primary postoperative adhesions. A randomized, prospective, blinded study. Academic research environment. Forty-one New Zealand Rabbits. A chemically modified hyaluronate and carboxymethylcellulose (HA/CMC) gel formulation was applied to a bilateral uterine horn injury. Postoperative adhesions were assessed at a second-look laparoscopy. The uterine horn model was shown to be adhesiogenic, with 29 (70%) of 42 untreated uterine horns found to have adhesions. After gel treatment, 22 (55%) of 40 uterine horns were free of adhesions compared with 12 (30%) of 42 controls. Animals treated with HA/CMC gel had significantly reduced postsurgical adhesion scores when compared with controls. Treatment of injured uterine horn with HA/CMC gel resulted in a significant reduction in postoperative surgical adhesions.

References

May 1, 1990·American Journal of Obstetrics and Gynecology·R E Leach, R L Henry
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B P TooleJ Gross
Jan 1, 1982·Connective Tissue Research·B P Toole

❮ Previous
Next ❯

Citations

Jul 13, 2002·Journal of Biomedical Materials Research·Lin-Shu Liu, Richard A Berg
Jul 13, 2002·Journal of Biomedical Materials Research·Toshihiro HabaraTakafumi Kudo
Apr 18, 2008·Archives of Gynecology and Obstetrics·Suzi DemirbagNarter Yesildaglar
Oct 17, 2009·Archives of Gynecology and Obstetrics·Orhan AksakalLeyla Mollamahmutoglu
Sep 13, 2011·Archives of Gynecology and Obstetrics·Evrim ErdemogluTamer Mungan
Jun 29, 2012·Archives of Gynecology and Obstetrics·Bulent UysalAhmet Korkmaz
Jun 5, 2012·Journal of Materials Science. Materials in Medicine·Seung Yeon NaJin Ho Lee
Jan 5, 2012·Human Reproduction·Mehmet Serdar KutukAhmet Ozturk
Sep 25, 1999·Current Opinion in Obstetrics & Gynecology·N Panay, A M Lower
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hakan OzelMustafa Sahin
Oct 27, 2004·The Tohoku Journal of Experimental Medicine·Sefa KelekciSelma Tokucoğlu
May 15, 2004·American Journal of Veterinary Research·Randy B EgglestonErin S Groover
Oct 12, 2011·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Patrick F VetereLorna Ogden
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Eduardo Esteban Montalvo-JavéJesús Tapia Jurado
Apr 17, 2016·The Journal of Surgical Research·Xiao-Dong LiHai-Ying Gu
Jan 6, 2004·Journal of Biomedical Materials Research. Part a·Xiao Zheng ShuGlenn D Prestwich
Jul 27, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fazli DemirturkAhmet C Caliskan
Aug 11, 2015·Current Problems in Surgery·Robel T BeyeneAdrian Barbul
Aug 28, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Serkan KahyaogluMahmut Nedim Cicek
Sep 13, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Cem BatukanIptisam I Muderris
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yoon Yeo, Daniel S Kohane
Sep 27, 2016·International Journal of Molecular Sciences·Guangbing WeiXuqi Li
Feb 26, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X H DuG H Liu
Dec 13, 2016·The Journal of Obstetrics and Gynaecology Research·Gürhan GüneyAytekin Tokmak
Jun 2, 2006·Journal of Biomedical Materials Research. Part a·Yoon YeoDaniel S Kohane
Sep 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gere S diZeregaRichard Berg
Oct 23, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bing YangYu Quan Wei
Nov 5, 2005·Journal of Biomedical Materials Research. Part a·P Roychowdhury, V Kumar
Jun 19, 2009·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Mustafa BasaranMesut Gul
Jul 18, 2019·Journal of Cellular Physiology·Atena SoleimaniSeyed Mahdi Hassanian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.