Reduction of proteinuria by rosiglitazone in non-diabetic renal disease

Nephrology
Priscilla Kincaid-SmithJoseph Proietto

Abstract

To investigate the effect of a thiazolidinedione on proteinuria in patients with non-diabetic renal disease. In an open-label randomized cross-over study, 40 adults with chronic non-diabetic renal disease completed the study. In a random fashion, one group was treated for 4 months with 4 mg of rosiglitazone first followed by a 4-month period of standard treatment. The opposite order was used for the second group. Baseline urinary protein excretion rate was 1.45 g/24 h. On rosiglitazone, there was a drop of urinary protein level of 0.24 g/24 h (P=0.045). In contrast, there was a trend for proteinuria to increase during the control period (0.12 g/24 h, P=0.18). The urine protein level on rosiglitazone was lower than on usual treatment (0.36 g/24 h, P=0.002, 95% CI 0.15-0.58). There was a similar beneficial effect on systolic blood pressure which was reduced by rosiglitazone by 7.8 mmHg (P=0.006, 95% CI 2.6-13.1). Although average fasting glucose was only 5.8 mmol/L, there was a significant Spearman correlation between fasting glucose and a reduction in urinary protein levels (r=0.34, P=0.045). It is concluded that thiazolidinediones may have a role in the management of non-diabetic proteinuria of various aetiologies. In this stud...Continue Reading

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Citations

Jan 18, 2008·Nephrology·Cheuk-Chun Szeto, Philip Kam-Tao Li
Oct 15, 2009·Diabetology & Metabolic Syndrome·Themis ZelmanovitzLuís H Canani
Dec 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Melanie S JoyHoward Trachtman
May 21, 2009·Nature Reviews. Nephrology·Eswari Vilayur, David C H Harris
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Mar 9, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Damien Noone, Christoph Licht
Aug 3, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnes B Fogo
Aug 15, 2014·American Journal of Physiology. Renal Physiology·David M SmallGlenda C Gobe
Oct 16, 2013·Molecular Medicine Reports·Ying HuangXueqing Yu
Oct 5, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Caroline Platt, Richard J Coward
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XiaoKar Neng Lai

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