Reduction of proteinuria; combined effects of receptor blockade and low dose angiotensin-converting enzyme inhibition

Journal of Hypertension
Elke D BergerChristiane M Erley

Abstract

Angiotensin-converting enzyme inhibitors (ACEI) show an antiproteinuric and thus nephroprotective effect in patients suffering from glomerulonephritis. Angiotensin II-receptor-antagonists (AT1RA) are also efficacious in reducing proteinuria. The study was performed to investigate the antiproteinuric effect of AT1RA candesartan in patients diagnosed with chronic glomerulonephritis by biopsy, and who were already being treated with an ACEI. A total of 12 patients with a persistent proteinuria of at least 1 g/day who were already being treated with an ACEI for more than 3 months were included. The study was performed using a double-blind, placebo-controlled and randomized method with two treatment periods of 8 weeks (placebo or candesartan 8 mg/day) and a wash-out period of 4 weeks in between. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by inulin- and PAH-clearances at the beginning and the end of each treatment period. Proteinuria significantly decreased from 2 +/- 0.4 g/day to 1.3 +/- 0.3 g/day (P < 0.05) with the addition of candesartan treatment, whereas it remained unchanged (from 1.8 +/- 0.3 g/day to 1.9 +/- 0.3 g/day) under placebo. GFR (candesartan: from 66 +/- 13 to 58 +/- 11 ml/m...Continue Reading

References

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Citations

May 2, 2003·Current Hypertension Reports·Paolo Palatini
Sep 3, 2004·Current Hypertension Reports·Niels H Andersen, Carl E Mogensen
Dec 9, 2004·Current Opinion in Nephrology and Hypertension·Raimund Hirschberg, Shinong Wang
Jan 7, 2010·Current Opinion in Nephrology and Hypertension·Maartje C J SlagmanGozewijn D Laverman
Jan 1, 2010·Current Opinion in Pediatrics·Elke Wühl, Franz Schaefer
May 13, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fausta CatapanoGiuseppe Conte
Jun 27, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin MacKinnonHeather D Clark
Sep 15, 2004·The Journal of Clinical Hypertension·Joseph L IzzoUNKNOWN AMAZE
Jan 12, 2007·The Journal of Clinical Hypertension·Domenic A Sica
Aug 31, 2006·International Journal of Clinical Practice·N R RoblesE Sánchez Casado
Mar 31, 2009·European Journal of Internal Medicine·N R RoblesJ J Cubero
Sep 14, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Domenic A Sica
Sep 29, 2005·American Journal of Physiology. Renal Physiology·Max C LiebauKarl-Georg Fischer
May 31, 2008·Expert Review of Cardiovascular Therapy·Katarzyna Kolasinska-MalkowskaAndrzej Tykarski
Mar 23, 2002·Journal of Hypertension·Herbert Thurston
Dec 14, 2016·BioMed Research International·Yufan CaoYamei Jin

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