PMID: 2504118Jul 1, 1989Paper

Reduction of reperfusion injury with mannitol cardioplegia

The Annals of Thoracic Surgery
R FerreiraA Boveris

Abstract

Forty consecutive patients undergoing myocardial revascularization were divided into two equal groups: group 1 received standard cardioplegic solution, and group 2 received a solution containing mannitol, 59.8 mmol/L. In 6 patients in each group, myocardial biopsies were done before ischemia and at the time of reperfusion. Samples were assessed by chemiluminescence to determine oxidative stress and by electron microscopic studies. A significant reduction in atrial arrhythmias was observed in the mannitol group. Chemiluminescence in group 1 showed a photoemission of 37.6 +/- 3.5 cpm/mg of protein x 10(-3) for the preischemia samples and 74.8 +/- 16 cpm/mg of protein x 10(-3) for the reperfusion samples (p less than 0.001). In group 2, the values for chemiluminescence were 37.7 +/- 3.4 cpm/mg of protein x 10(-3) and 40 +/- 6.1 cpm/mg of protein x 10(-3), respectively (p = not significant). Electron microscopic studies showed, for group 1, increased grades of damaged mitochondria in the reperfusion biopsy specimens compared with the preischemia biopsy specimens (p less than 0.01). In group 2, differences for damaged mitochondria were not significant. These results support the hypothesis that mannitol reperfusate significantly redu...Continue Reading

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Citations

Apr 12, 1995·Molecular and Cellular Biochemistry·S LlesuyA Boveris
Mar 31, 2004·Molecular Aspects of Medicine·Danilo Wilhelm FilhoAlberto Boveris
Sep 6, 2003·International Journal of Cardiology·Ricardo FerreiraJosé Milei
Jan 1, 1997·Free Radical Biology & Medicine·N KozlovskyN Bashan
Jul 13, 1999·Free Radical Biology & Medicine·F CarrasquedoC G Fraga
Oct 12, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E M Hoenicke, R J Damiano
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L XiongP Menasché
Apr 9, 2001·Antioxidants & Redox Signaling·M C ToufektsianJ G de Leiris
Feb 28, 2001·Journal of Cardiac Surgery·C B Huddleston, E N Mendeloff
Feb 1, 1993·The Journal of Clinical Investigation·B González-FlechaA Boveris
Feb 13, 2001·Journal of Molecular and Cellular Cardiology·R SalieA Lochner
Mar 14, 2009·Scandinavian Journal of Immunology·S ZiegelerH Rensing
Apr 29, 2016·Oxidative Medicine and Cellular Longevity·Daniel Fudulu, Gianni Angelini
Jul 12, 2005·Biochimica Et Biophysica Acta·Claudia R RhodenBeatriz González-Flecha
Jan 8, 1999·The Journal of Surgical Research·F W SellkeD L Ely
Jun 15, 2004·Journal of the American College of Cardiology·José MileiGiuseppe Ambrosio
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·E M HoenickeR J Damiano
Jan 1, 1996·Free Radical Research·C E GillbeJ M Gutteridge
Oct 1, 1991·Circulation Research·R C KukrejaM L Hess
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Sep 23, 2011·Inhalation Toxicology·Miriam LemosBeatriz Gonzalez-Flecha
May 18, 1999·The American Journal of Physiology·G DunphyD Ely
Apr 13, 1995·Biochimica Et Biophysica Acta·B González-Flecha, A Boveris
Mar 31, 2004·Molecular Aspects of Medicine·Beatriz González-Flecha
Jul 1, 2008·Transplantation Proceedings·L F TirapelliA C P Martins

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