Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination

Journal of Virology
Dan H BarouchNorman L Letvin

Abstract

Since cytotoxic T lymphocytes (CTLs) are critical for controlling human immunodeficiency virus type 1 (HIV-1) replication in infected individuals, candidate HIV-1 vaccines should elicit virus-specific CTL responses. In this report, we study the immune responses elicited in rhesus monkeys by a recombinant poxvirus vaccine and the degree of protection afforded against a pathogenic simian-human immunodeficiency virus SHIV-89.6P challenge. Immunization with recombinant modified vaccinia virus Ankara (MVA) vectors expressing SIVmac239 gag-pol and HIV-1 89.6 env elicited potent Gag-specific CTL responses but no detectable SHIV-specific neutralizing antibody (NAb) responses. Following intravenous SHIV-89.6P challenge, sham-vaccinated monkeys developed low-frequency CTL responses, low-titer NAb responses, rapid loss of CD4+ T lymphocytes, high-setpoint viral RNA levels, and significant clinical disease progression and death in half of the animals by day 168 postchallenge. In contrast, the recombinant MVA-vaccinated monkeys demonstrated high-frequency secondary CTL responses, high-titer secondary SHIV-89.6-specific NAb responses, rapid emergence of SHIV-89.6P-specific NAb responses, partial preservation of CD4+ T lymphocytes, reduced se...Continue Reading

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Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·D H BarouchN L Letvin

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Citations

Jan 8, 2003·The Journal of Gene Medicine·Matilu Mwau, Andrew J McMichael
Oct 21, 2006·Springer Seminars in Immunopathology·Franco LoriJulianna Lisziewicz
Nov 6, 2008·Medical Microbiology and Immunology·Sanjay MendirattaVishnubhatla Sreenivas
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Aug 11, 2001·Current Opinion in Immunology·D H Barouch, N L Letvin
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Apr 25, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frances H PriddyUNKNOWN Merck V520-016 Study Group
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