Reduction of skin innervation is associated with a severe fibromyalgia phenotype

Annals of Neurology
Dimitar EvdokimovNurcan Üçeyler

Abstract

To assess patterns and impact of small nerve fiber dysfunction and pathology in patients with fibromyalgia syndrome (FMS). One hundred seventeen women with FMS underwent neurological examination, questionnaire assessment, neurophysiology assessment, and small fiber tests: skin punch biopsy, corneal confocal microscopy, microneurography, quantitative sensory testing including C-tactile afferents, and pain-related evoked potentials. Data were compared with those of women with major depressive disorder and chronic widespread pain (MD-P) and healthy women. Intraepidermal nerve fiber density (IENFD) was reduced at different biopsy sites in 63% of FMS patients (MD-P: 10%, controls: 18%; p < 0.001 for each). We found 4 patterns of skin innervation in FMS: normal, distally reduced, proximally reduced, and both distally and proximally reduced (p < 0.01 for each compared to controls). Microneurography revealed initial activity-dependent acceleration of conduction velocity upon low frequencies of stimulation in 1A fibers, besides 1B fiber spontaneous activity and mechanical sensitization in FMS patients. FMS patients had elevated warm detection thresholds (p < 0.01), impaired C-tactile afferents (p < 0.05), and reduced amplitudes (p < 0.0...Continue Reading

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Citations

Jun 17, 2019·The Journal of Rheumatology·Dimitar EvdokimovNurcan Üçeyler
Jan 17, 2020·Muscle & Nerve·Majid Ghasemi, Yusuf A Rajabally
Feb 7, 2020·Current Medical Research and Opinion·Domenico Merante
Dec 18, 2019·Journal of the Peripheral Nervous System : JPNS·Alexander KlitschNurcan Üçeyler
Jun 2, 2020·European Journal of Pain : EJP·Eleonora VecchioMarina de Tommaso
Jun 14, 2020·European Journal of Pain : EJP·Helena H KaziyamaDaniel Ciampi de Andrade
Jan 14, 2020·PloS One·Dimitar EvdokimovNurcan Üçeyler
Sep 29, 2020·NeuroRehabilitation·Stoyan PopkirovConstanze Hausteiner-Wiehle
Jan 10, 2021·The Journal of Pain : Official Journal of the American Pain Society·Richard J BerwickAndreas Goebel
Mar 3, 2021·Pediatric Rheumatology Online Journal·Maya Levy ColesYosef Uziel
Aug 18, 2020·Neurobiology of Disease·Julia ForstenpointnerDavid Borsook
Aug 18, 2020·The Journal of Rheumatology·Alexis BoneparthAnne Louise Oaklander
Feb 10, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Antonello VicecontiMarco Testa
Jun 5, 2021·Journal of the Peripheral Nervous System : JPNS·Maryam FerdousiRayaz A Malik
Jun 16, 2021·Brain : a Journal of Neurology·Steven J MiddletonDavid L Bennett
Jun 4, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Florian Bailly
Jul 2, 2021·The Journal of Clinical Investigation·Andreas GoebelDavid A Andersson
Jul 16, 2021·Pharmacology & Therapeutics·Evelyne Silva BrumSara Marchesan Oliveira
Jul 28, 2021·The British Journal of Ophthalmology·Gulfidan BitirgenRayaz A Malik
Aug 3, 2021·Therapeutic Advances in Neurological Disorders·Nadine EgenolfNurcan Üçeyler
Aug 11, 2021·Muscle & Nerve·Franco GemignaniGiovanni Pavesi
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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