Reduction of sodium dependent stump currents disturbs urodele limb regeneration

The Journal of Experimental Zoology
R B BorgensL F Jaffe

Abstract

We have asked the question whether the natural electric currents which leave urodele limb stumps are in any way needed for their regeneration. As an initial test, we have greatly reduced such currents in the tiger salamander, Ambystoma tigrinum, by applying 0.5 mM amiloride to the stump skin or by immersion of the animals in sodium depleted media. We have also reduced such currents in the red spotted newt, Notophthalmus viridescens, by such immersion. Limb regeneration in half of the amiloride-treated animals was either entirely blocked or grossly deficient, while the others regenerated normally. Limb regeneration in sodium depleted media was consistently inhibited for some weeks but then recovered. These results are consistent with the hypothesis that stump currents are in some way needed for normal regeneration.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B BorgensL F Jaffe
Jun 1, 1977·The Journal of Experimental Zoology·R B BorgensL F Jaffe
Oct 13, 1972·Science·R D McAfee, H M Kalckar
Jan 1, 1974·Annals of the New York Academy of Sciences·S D Smith
Jun 1, 1970·Acta Physiologica Scandinavica·R Nielsen, R W Tomilson
Dec 1, 1973·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Laurie E Iten, Susan V Bryant

❮ Previous
Next ❯

Citations

Aug 14, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A M AltizerR B Borgens
Jul 1, 1979·The Journal of Experimental Zoology·R B BorgensL F Jaffe
Aug 1, 1988·Developmental Biology·A M RajnicekK R Robinson
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·E M EltingeJ W Vanable
Mar 29, 2014·PloS One·Joana MonteiroJoaquín Rodríguez-León
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ai-Sun TsengMichael Levin
Jan 1, 1984·Differentiation; Research in Biological Diversity·R B Borgens
Feb 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yuval RinkevichSubhro K Sen
Apr 16, 2013·The Biochemical Journal·Juan Felipe Diaz Quiroz, Karen Echeverri
Sep 5, 2006·Developmental Biology·Donald L AtkinsonShannon J Odelberg
Jul 1, 1984·Clinics in Dermatology·L F Jaffe, J W Vanable
Dec 19, 2002·The Journal of Experimental Zoology·Alicia M AltizerRichard B Borgens
Jun 24, 2003·Bioelectromagnetics·Michael Levin
Jan 1, 1988·The Journal of Experimental Zoology·M M Bever, R B Borgens
Aug 1, 1984·The Journal of Experimental Zoology·R B BorgensE S Miles
Jun 10, 1982·The Journal of Experimental Zoology·K S Chang, J W Snellen
Dec 1, 1983·The Journal of Experimental Zoology·R B BorgensL E DeLanney
Oct 5, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Varun B Dwaraka, S Randal Voss
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Hugo Varela-RodríguezAlfredo Cruz-Ramirez
Jan 6, 2021·BMC Biomedical Engineering·Christina N M RyanDimitrios I Zeugolis
Sep 27, 2007·Science's STKE : Signal Transduction Knowledge Environment·Jonathan M W Slack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.