Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog

Journal of Neurosurgery
Yuji TaokaK Takatsuki

Abstract

To investigate whether iloprost, a stable analog of prostacyclin, is useful for the prevention of posttraumatic spinal cord injury, we examined its effects on compression trauma-induced spinal cord injury in rats. Spinal cord injury was induced by applying a 20-g weight for 20 minutes to the spinal cord at the level of T-12, resulting in motor disturbances in the hindlimbs. These motor disturbances, evaluated using Tarlov's index, were markedly attenuated in rats with nitrogen mustard-induced leukocytopenia. Administration of iloprost also attenuated the motor deficits. Histological examination revealed that intramedullary hemorrhages observed 24 hours after trauma were significantly attenuated in leukocytopenic animals and in animals that received iloprost. The accumulation of leukocytes at the site of trauma, evaluated by measuring tissue myeloperoxidase activity, significantly increased with time following the trauma, peaking at 3 hours postinjury. Spinal cord myeloperoxidase activity in sham-operated animals did not increase postoperatively. Leukocyte depletion and administration of iloprost reduced the accumulation of leukocytes in the damaged spinal cord segment 3 hours posttrauma. These findings indicate that iloprost at...Continue Reading

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Citations

Mar 15, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alicia L Hawthorne, Phillip G Popovich
Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Dec 4, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D CarbajalJ E Gonzalez
Feb 21, 2002·Journal of Neurotrauma·Sean D HurleyM Kerry O'Banion
Apr 11, 2000·Journal of Neurotrauma·Y Taoka, K Okajima
Feb 3, 2005·Journal of Neurotrauma·Yuji TaokaMitsuhiro Uchiba
Dec 23, 2006·Journal of Neurotrauma·Naoaki HaradaKenji Okajima
Oct 5, 2001·Clinical Neuropharmacology·R J DumontA S Dumont
Sep 30, 2000·Journal of Neurosurgery·K Al MoutaeryM Tariq
Dec 7, 2007·Clinical Neuroscience Research·Alpa TrivediLinda J Noble-Haeusslein
Oct 19, 2006·Neuropharmacology·Taisuke KitamuraKenji Okajima
Jul 11, 2003·Clinics in Sports Medicine·David O Okonkwo, James R Stone
Dec 20, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M BogaI Meteoglu
Aug 29, 2003·Neurosurgery·Khalaf Al MoutaeryMohammad Tariq
Oct 3, 2006·Current Opinion in Anaesthesiology·T Brüssel

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