Reduction of the ex vivo production of tumor necrosis factor alpha by alveolar phagocytes after administration of coal fly ash and copper smelter dust

Journal of Toxicology and Environmental Health
F BroeckaertJ W Yager

Abstract

We investigated the effect of intratracheally instilled coal fly ash (FA) and copper smelter dust (CU) on the lung integrity and on the ex vivo release of tumor necrosis factor alpha (TNF-alpha) by alveolar phagocytes. Groups of female NMRI mice received a single intratracheal administration of different particles normalized for the arsenic content (20 micrograms/kg body weight, i.e., 600 ng arsenic/mouse) and the particle load (100 mg/kg body weight, i.e., 3 mg/mouse). Mice received tungsten carbide (WC) alone (100 mg/kg), FA alone (100 mg/kg, i.e., 20 micrograms arsenic/kg), CU mixed with WC (CU, 13.6 mg/kg, i.e., 20 micrograms arsenic/kg; WC, 86.4 mg/kg) and Ca3(AsO4)2 mixed with WC (20 micrograms arsenic/kg; WC, 100 mg/kg). Animals were sacrificed at 1, 6, or 30 d posttreatment and analyzed by bronchoalveolar lavage for total protein (TP) content, inflammatory cell number and type, and TNF-alpha production. Additional mice were studied to evaluate particle retention by measuring total arsenic retention in the lung at appropriate times. Instillation of WC induced a mild and transient (d 1) inflammatory reaction characterized by an increase of TP and an influx of polymorphonuclear leukocytes in the alveolar compartment. Compa...Continue Reading

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Citations

Sep 14, 2002·Journal of Toxicology and Environmental Health. Part a·Srikanth S Nadadur, Urmila P Kodavanti
Sep 14, 2002·Journal of Toxicology and Environmental Health. Part a·Kaoru HamadaLester Kobzik
Aug 9, 2002·Journal of Toxicology and Environmental Health. Part a·Song-Lih HuangChang-Chuan Chan
Jul 12, 2003·Journal of Toxicology and Environmental Health. Part a·Ines PaganJanice A Dye
Dec 6, 2005·Journal of Toxicology and Environmental Health. Part a·Ji Young KimJai Youl Ro
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Cai-Yun ZhongKent E Pinkerton
Jul 26, 2006·Journal of Occupational and Environmental Hygiene·Jeffrey Hicks, Janice Yager
Aug 10, 2000·Environmental Health Perspectives·P KelleherL S Newman
Jul 19, 2013·Journal of the Air & Waste Management Association·Eric N Liberda, Lung Chi Chen
Jun 26, 2013·Inhalation Toxicology·Karen TaylorDavid C Dorman
Jun 24, 1999·Inhalation Toxicology·J A DormansH van Loveren

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