PMID: 6990674Jan 1, 1980Paper

Reduction of the risk of acid pulmonary aspiration in anaesthetized patients after cimetidine premedication

Acta Anaesthesiologica Scandinavica
M SalmenperäT V Kalima

Abstract

Forty-two patients undergoing elective general surgery received either placebo, cimetidine 300 mg, or cimetidine 600 mg orally 1.5-2 h before anaesthesia in a double-blind, randomized study. Another 13 subjects received no oral premedication and served as a control group. When compared to placebo or control patients, both doses of cimetidine significantly (P less than 0.01) decreased the acidity and volume of gastric contents. None of the subjects given cimetidine were in the risk range of acid pulmonary aspiration (pH under 2.5 plus volume over 25 ml), whereas 46% of the control patients and 40% of the patients given placebo (P less than 0.005 vs cimetidine in both groups) were in the risk range.

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W L BurlandJ H Wyllie
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·I TakayanagiY Kasuya
Oct 1, 1978·Anaesthesia·R P HusemeyerT Rajasekaran
Dec 1, 1978·British Journal of Anaesthesia·P J KeatingD W Watson
Aug 1, 1976·Anesthesiology·H H Ali, J J Savarese
Aug 21, 1975·The New England Journal of Medicine·R M HennR A Sturdevant
Feb 2, 1978·The New England Journal of Medicine·C G Brook
Nov 1, 1974·Anesthesia and Analgesia·R B Roberts, M A Shirley

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Citations

Jun 1, 1986·Annals of Surgery·H L LawsA S Wheeler
May 1, 1983·Canadian Anaesthetists' Society Journal·J G Williams
Nov 1, 1983·Canadian Anaesthetists' Society Journal·A S OkashaA Bali
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·G L Olsson, B Hallén
Aug 29, 2017·Journal of Surgical Oncology·Ankit SarinElizabeth C Wick
Sep 17, 1981·The New England Journal of Medicine
Jan 1, 1986·Acta Anaesthesiologica Scandinavica·G L OlssonK Hambraeus-Jonzon
May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky

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