Reduction of the somatotrope responsiveness to GHRH and Hexarelin but not to arginine plus GHRH in hyperprolactinemic patients

Journal of Endocrinological Investigation
S GrottoliE Ghigo

Abstract

Aim of the present study was to verify the maximal secretory capacity of somatotrope cells in patients with pathological hyperprolactinemia (HPRL) comparing it with that in normal age-matched women (NW). To this goal in 12 HPRL normal weight patients (age 28.6 +/- 2.6 yr, BMI 23.1 +/- 1.1 kg/m2) and 8 NW (27.2 +/- 0.8 yr, 22.8 +/- 0.8 kg/m2) we studied the GH response to GHRH (1 microgram/kg i.v.), GHRH plus arginine (ARG, 0.5 g/kg i.v.), an amino acid probably acting at the hypothalamic level inhibiting somatostatin release, and Hexarelin (HEX, 2 micrograms/kg i.v.), a synthetic hexapeptide belonging to GHRP family, which acts concomitantly at the pituitary and the hypothalamic level. IGF-I levels in HPRL were similar to those in NW (179.2 +/- 16.5 micrograms/l and 218.5 +/- 30.8 micrograms/l). In NW the GH response to GHRH (AUC: 1299.5 +/- 186.9 micrograms 90 min/l) was lower (p < 0.02) than those to GHRH + ARG (5252.7 +/- 846.3 micrograms 90 min/l) and HEX 3216.6 +/- 462.3 micrograms 90 min/l) which, in turn, were similar. In HPRL the GH response to GHRH (894.7 +/- 242.4 micrograms 90 min/l) was lower (p < 0.03) than that to HEX (1586.5 +/- 251.3 micrograms 90 min/l) and both were lower (p < 0.03) than that to GHRH + ARG (44...Continue Reading

References

Apr 1, 1977·Diabetologia·R LandgrafP C Scriba
Oct 1, 1992·Journal of Endocrinological Investigation·E GhigoM F Boghen
Aug 1, 1991·Endocrine Reviews·P A KellyM Edery
Oct 1, 1989·Journal of Endocrinological Investigation·F CamanniE E Müller
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J Alba-RothK von Werder
May 1, 1984·The Journal of Clinical Investigation·S Melmed
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·F MassaraF Camanni
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·D DallabonzanaA Liuzzi
Apr 1, 1981·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsJ J Van Wyk
Jan 1, 1995·Neuroendocrinology·E ArvatE Ghigo
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jan 1, 1995·Metabolism: Clinical and Experimental·M MaccarioE Ghigo
Feb 1, 1993·Endocrine Reviews·E CorpasM R Blackman
Mar 1, 1996·European Journal of Endocrinology·E GhigoF Camanni
May 1, 1997·European Journal of Endocrinology·E GhigoF Camanni

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