Reduction of the total IgE level by omalizumab in children and adolescents

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Jens-Oliver SteissH Lindemann

Abstract

Current data from clinical studies show that patients with severe allergic asthma experience a significant improvement from omalizumab. The early and late allergic reactions are inhibited by formation of complexes with free circulating immunoglobulin E (IgE), independent of which antigen activates the allergic cascade. The dosage of omalizumab depends on body weight and IgE level, yet no parameter has been established to guide dosage changes during therapy. The aim of this study was to investigate the value of the determination of total IgE by ADVIA Centaur assay to monitor the therapy progress. Nine patients, 8 to 17 years of age, received therapy with omalizumab due to severe allergic bronchial asthma. In addition, the patients had pronounced rhinoconjunctivitis, food allergy, insect sting allergy, and/or neurodermitis. The total IgE in the serum (Sandwich-Immunoassay ADVIA Centaur) was measured in the patients once monthly before each omalizumab injection as a potential progress parameter. Six months after the beginning of therapy with omalizumab, a significant decrease of the total IgE concentration was found, in comparison to the baseline values (p < 0.01). In all patients, the tolerability of omalizumab was very good; the...Continue Reading

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Citations

Apr 16, 2009·Clinical Microbiology Reviews·Edsel Maurice T Salvana, Robert A Salata
Jun 10, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ji Young KangSook Young Lee
Feb 5, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Raymond G Slavin, Pablo Jimenez
Jun 17, 2009·Expert Opinion on Biological Therapy·Dennis Keith Ledford
Mar 12, 2011·British Journal of Clinical Pharmacology·Philip J Lowe, Didier Renard
Sep 6, 2012·International Archives of Allergy and Immunology·Stefan ZielenVeit J Erpenbeck
Feb 11, 2012·Therapeutic Advances in Respiratory Disease·Francesco MenzellaLuigi Zucchi
Dec 16, 2010·The Korean journal of laboratory medicine·Seoung Won JungYong Jin Park
Jan 19, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M M RauberW Pfützner
Jan 30, 2019·Endocrine Connections·Nicola TuftonHelen L Storr
Oct 17, 2014·Journal of Animal Physiology and Animal Nutrition·M SridharV Thammiaha
Jul 27, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jens-Oliver SteissKlaus-Peter Zimmer
Nov 30, 2019·Italian Journal of Pediatrics·Mattia GiovanniniElio Novembre
Dec 12, 2020·Heliyon·Suteeraporn ChaowattanapanitMongkhon Sompornrattanaphan
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology
May 21, 2009·Current Opinion in Allergy and Clinical Immunology

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