PMID: 6972158Jun 1, 1981Paper

Reduction of thrombosis in canine coronary bypass vein grafts with dipyridamole and aspirin

The American Journal of Cardiology
M JosaM P Kaye

Abstract

The potential benefit of platelet inhibitor drugs in reducing early thrombosis of coronary arterial vein bypass grafts was assessed in dogs. There were 26 control dogs and 24 dogs treated with dipyridamole, 55 mg/day plus aspirin, 325 mg/day. The dogs in both groups were killed at 2 hours and 1, 2, 3, 7 and 14 days after operation. The grafts were perfused with fixative in vivo, harvested and examined with light microscopy. Severe alterations of the graft wall were observed in the dogs in both groups. The grafts in the control group had a high incidence rate of thrombosis, which occurred early after the operation; those in the treated group had a significantly reduced incidence of thrombosis (p = 0.025). Our study indicates that a combined regimen of dipyridamole and aspirin is effective in reducing early graft thrombosis in dogs.

References

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Citations

Apr 1, 1991·Clinical Cardiology·D H IsraelV Fuster
Oct 1, 1989·Journal of the American College of Cardiology·B SteinJ H Chesebro
Jun 1, 1990·Journal of the American College of Cardiology·J H IpJ H Chesebro
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A R DresdaleN A Silverman
Jul 13, 1984·The American Journal of Medicine·M P KayeM E Lovaas
Feb 1, 1985·Journal of the American College of Cardiology·T A MabinT A Orszulak
Dec 2, 1982·The New England Journal of Medicine·H Gohlke, C Gohlke-Bärwolf
Jan 26, 1984·The New England Journal of Medicine·J H ChesebroF J Puga
Jun 7, 1984·The New England Journal of Medicine·C von Schacky
Jul 1, 1988·Current Problems in Cardiology·W J PennyV Fuster
Apr 1, 1984·The Journal of Surgical Research·R J RobisonJ W Brown
Mar 13, 2016·Journal of Veterinary Pharmacology and Therapeutics·J ThomasonA Mackin
Mar 29, 2008·Stroke; a Journal of Cerebral Circulation·Martin J O'DonnellJohn W Eikelboom
Oct 16, 2018·Cardiovascular & Hematological Disorders Drug Targets·Trevor SimardBenjamin Hibbert
Feb 1, 1986·Current Problems in Cardiology·W H Frishman, K P Miller

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