Reduction of thyrotropin-releasing hormone concentrations in central nervous system of African lungfish during estivation

General and Comparative Endocrinology
M S KreiderA P Fishman

Abstract

Thyrotropin-releasing hormone (TRH) has been implicated as an important modulator of arousal state in mammals. Changes in the content of TRH in several brain regions accompany hibernation in the ground squirrel. In the present study, the involvement of TRH in the regulation of arousal was further investigated in the African lungfish, Protopterus annectens, which contain high concentrations of TRH throughout its central nervous system and enter a hibernation-like state, estivation. Lungfish were divided into three groups. Group 1 was fed normally, group 2 was starved while aquatic, and group 3 was allowed to enter into a state of estivation. After 3 months, the lungfish were sacrificed and the concentrations of TRH, norepinephrine, dopamine, and serotonin were determined in the telencephalon, diencephalon, medulla, and spinal cord. In estivation, there was a significant decline in the concentration of TRH in the diencephalon, with no alteration in other regions. Starvation had no effect on regional TRH concentrations. The concentration of norepinephrine, dopamine, and serotonin did not change in estivation; however, a significant elevation of norepinephrine in the diencephalon and dopamine in the telencephalon was observed in st...Continue Reading

Citations

Oct 1, 1994·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M GuppyJ E Flanigan
Jan 1, 2012·Journal of Experimental Stroke & Translational Medicine·Shimin Liu, Jiang-Fan Chen
Dec 13, 2005·General and Comparative Endocrinology·Jean M P Joss
Dec 22, 1999·The American Journal of Physiology·J M Cerdá-ReverterS Zanuy

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