PMID: 15231888Jul 3, 2004Paper

Reduction of tissue hyperplasia with a rhenium-188 mercaptoacetyltriglycine-3-filled balloon: preliminary study in a canine urethral model

Journal of Vascular and Interventional Radiology : JVIR
Ji Hoon ShinJean Hwa Lee

Abstract

To evaluate the efficacy of beta-radiation therapy with rhenium-188 mercaptoacetyltriglycine-3 (MAG(3))-filled balloons to reduce tissue hyperplasia secondary to stent placement in 18 canine urethras. Eight dogs were treated with 188-Re MAG(3)-filled balloon dilation immediately after stent placement and were killed 4 weeks later (group I, n = 4) or 8 weeks later (group II, n = 4). Five dogs were treated with 188-Re MAG(3)-filled balloon dilation 2 weeks after stent placement and were killed 4 weeks after stent placement (group III). The remaining five dogs were treated with conventional balloon dilation immediately after stent placement and were killed 4 weeks later; these animals formed the control group (group IV). Retrograde urethrography (RUG) was performed during follow-up and three histologic parameters were investigated: the number of epithelial layers, papillary projection thickness, and degree of submucosal inflammatory cell infiltration. The areas inside and outside the ends of the stents were evaluated in each case after animal sacrifice. After testing statistical significance of data for RUG and histologic findings in the four study groups, the Mann-Whitney U test was used to compare groups I and II to determine de...Continue Reading

References

Sep 1, 1976·AJR. American Journal of Roentgenology·D S LevyR E Roth
Feb 15, 2001·The New England Journal of Medicine·M B LeonR E Kuntz
May 29, 2002·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Eun-Hee KimSeong-Wook Park

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Citations

Mar 11, 2006·European Radiology·Ji Hoon ShinKyu-Bo Sung
Nov 22, 2007·AJR. American Journal of Roentgenology·Eugene K ChoiChoung-Soo Kim
Nov 21, 2012·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Sinisa MarkovicJochen Wöhrle

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