PMID: 6406214Jun 1, 1983Paper

Reduction of two-drug therapy in intractable epilepsy

Epilepsia
D Schmidt

Abstract

The effects of reducing two-drug treatment to single-drug therapy were studied prospectively in 36 patients with intractable complex partial seizures. In 30 patients (83%) this was possible without an increase in seizure frequency. In six patients (17%) the number of seizures was higher during single-drug therapy. The slow transfer was not complicated by unwanted withdrawal effects. The plasma concentration of the single drug was raised if necessary until clinical drug toxicity was observed. An improvement in seizure control was surprisingly noted in 13 patients (36%). In two patients seizures were completely controlled. In one patient a seizure reduction of 87% was observed. The number of patients with clinical side effects was similar during two-drug and single-drug therapy. The number of side effects was lower during single-drug therapy. Reduction of polypharmacy may be beneficial for patients with intractable epilepsy.

References

Jun 25, 1977·British Medical Journal·S D Shorvon, E H Reynolds
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Nov 1, 1983·Fortschritte der Neurologie-Psychiatrie·D Schmidt
Feb 1, 1981·Epilepsia·E H Reynolds, S D Shorvon
Dec 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·D Schmidt
Oct 1, 1982·Epilepsia·P J Thompson, M R Trimble

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Citations

Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·B F Bourgeois
Jan 1, 1986·European Journal of Clinical Pharmacology·G J MacpheeM J Brodie
Jan 1, 1992·Pharmacology & Therapeutics·W H Theodore
Nov 1, 1991·Pediatric Neurology·A Shuper, E P Vining
Nov 1, 1987·Epilepsy Research·J S Duncan, S D Shorvon
Sep 1, 1992·Seizure : the Journal of the British Epilepsy Association·D J ArmourS Balarajan
Nov 26, 2002·Epilepsy Research·Dieter SchmidtGregory L Holmes
Nov 26, 2002·Epilepsy Research·Gregory L Holmes
Nov 26, 2002·Epilepsy Research·Charles L P Deckers
Nov 26, 2002·Epilepsy Research·Blaise F D Bourgeois
Sep 1, 1995·Seizure : the Journal of the British Epilepsy Association·A Richens
Sep 1, 1994·Seizure : the Journal of the British Epilepsy Association·R M DasheiffJ R Lave
Apr 1, 1997·Seizure : the Journal of the British Epilepsy Association·S BhaumikI A Ismail
Jan 1, 1984·Epilepsia·O Dulac, M Arthuis
Jan 1, 1984·Epilepsia·O Henriksen, S I Johannessen
Jan 1, 1987·Epilepsia·W E Dodson
Jan 1, 1987·Epilepsia·E H Reynolds
Jan 1, 1988·Epilepsia·B F Bourgeois
Jul 1, 1989·Epilepsia·U SpechtP Wolf
Mar 1, 1989·Epilepsia·A KrumholzB J Stern
Aug 26, 2009·Epilepsia·Jacqueline A French, Edward Faught
Dec 1, 1996·Acta Neurologica Scandinavica·J Bauer
Dec 1, 1991·Archives of Disease in Childhood·J H Livingston
Nov 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·D Chadwick, D M Turnbull
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·P D Swanson
Jul 16, 2010·Neuropsychiatric Disease and Treatment·David M Treiman
Oct 17, 2006·Drugs·Patrick Kwan, Martin J Brodie
Mar 13, 2002·CNS Drugs·Charles L P Deckers
Apr 1, 1995·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N Y LorenzoW H Theodore
Mar 24, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Stacey Allison Smith, Jerry R McKee
Jun 1, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R S McLachlan, J Maher

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