Reduction of voltage-operated sodium currents by the anticonvulsant drug sulthiame

Brain Research
Michael MadejaE J Speckmann

Abstract

The effect of the sulfonamide derivative sulthiame (Ospolot) on voltage-operated sodium channels was investigated in acutely isolated neurons from the guinea pig hippocampus using the whole-cell patch-clamp technique. Sulthiame in a concentration of 10 microg/ml reduced the inactivating sodium currents without affecting potassium currents. The effect was not dependent on voltage. At therapeutic concentration of 1 to 10 microg/ml sodium currents were reduced by 13 to 25% of control. Reductions of this size (induced by the specific sodium channel blocker tetrodotoxin or by 10 microg/ml sulthiame itself) impaired repetitive generation of action potentials and reduced the maximum discharge frequency by 20 to 40%. In summary, the anticonvulsant drug sulthiame exerts blocking effects on sodium channels which can be assumed to be anticonvulsant and to be different from the effects induced by blockade of carbonic anhydrase.

References

May 1, 1975·Archives of Neurology·B S MeldrumP A Toseland
Jan 1, 1975·Acta Neurologica Scandinavica. Supplementum·P Lerman, E Nussbaum
Nov 1, 1977·The Journal of General Physiology·F Bezanilla, C M Armstrong
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C M TangM Morad
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T IijimaS Hagiwara
May 1, 1986·Journal of Neuroscience Methods·A R Kay, R K Wong
Jun 1, 1965·Biochemical Pharmacology·H TanimukaiZ Kaneko
Jun 1, 1982·Irish Journal of Medical Science·M P FeelyN Callaghan
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jul 1, 1980·Neuropharmacology·T E AlbertsonL G Stark
Jan 1, 1993·Epilepsia·R L Macdonald, K M Kelly

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Citations

May 24, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tohshin Go
May 5, 2005·Experimental Neurology·Daniela MantheyPetra Bittigau
Nov 9, 2002·Epilepsia·Rüdiger Köhling
Jul 15, 2009·The Journal of Physiology·Desdemona FrickerRichard Miles
Mar 6, 2003·Neurologic Clinics·Ann M Bergin, Mary Connolly
Dec 4, 2003·British Journal of Pharmacology·Démetrius Antonio Machado AraújoJader Santos Cruz
Sep 20, 2011·Seizure : the Journal of the British Epilepsy Association·Nina SwiderskaRichard Appleton
Jun 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Seda KanmazSarenur Gokben

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