Reduction sensitive hyaluronan-SS-poly(ε-caprolactone) block copolymers as theranostic nanocarriers for tumor diagnosis and treatment

Materials Science & Engineering. C, Materials for Biological Applications
Huikang YangXinqing Jiang

Abstract

Tumor-targeted multifunctional nanocarriers play an important role in tumor diagnosis and treatment. Herein, disulfide bonds linked amphiphilic hyaluronan-SS-poly(ε-caprolactone) diblock copolymers (HA-SS-PCL) were synthesized and studied as theranostic nanocarriers for tumor diagnosis and treatment. The chemical structure of HA-SS-PCL was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H NMR). The self-assembling behavior of the HA-SS-PCL into GSH-responsive micelles and their degradation were characterized by fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Theranostic nanocarriers encapsulating doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) were formed via a dialysis. In vitro drug release results suggested that the HA-SS-PCL micelles possessed reductant-triggered doxorubicin release ability, which was confirmed by 100% of DOX release from HA-SS-PCL micelles within 12 h under 10 mM of glutathione (GSH), whereas about 40% of DOX was released under non-reductive condition within 24 h. Both flow cytometry and confocal laser scanning microscopy (CLSM) analysis revealed that the HA-SS-PCL micelles loaded with DOX we...Continue Reading

Citations

Jul 5, 2019·Drug Development and Industrial Pharmacy·Xin-Cheng ZhongJian-Qing Gao
Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yufen Xiao, Jianzhong Du
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Nasrin ZohrehCristina Busuioc
Sep 7, 2019·ACS Applied Materials & Interfaces·Tianyi KangMaling Gou

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