Reduction-sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy

Advanced Drug Delivery Reviews
Huanli SunZhiyuan Zhong

Abstract

The development of smart delivery systems that are robust in circulation and quickly release drugs following selective internalization into target cancer cells is a key to precision cancer therapy. Interestingly, reduction-sensitive polymeric nanomedicines showing high plasma stability and triggered cytoplasmic drug release behavior have recently emerged as one of the most exciting platforms for targeted delivery of various anticancer drugs including small chemical drugs, proteins, and nucleic acids. In vivo studies in varying tumor models reveal that these reduction-sensitive multifunctional nanomedicines outperform the currently used clinical formulations and reduction-insensitive counterparts, bringing about not only significantly enhanced tumor selectivity, accumulation and inhibition efficacy but also markedly reduced systemic toxicity and improved therapeutic index. In this review, we will highlight the cutting-edge advancement with a focus on in vivo performances as well as future perspectives on reduction-sensitive polymeric nanomedicines for targeted cancer therapy.

Citations

Jun 15, 2019·Current Pharmaceutical Design·Anton Ficai
Apr 17, 2019·The Journal of Gene Medicine·Weiqi WangHaijun Yu
Aug 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuman DongPeng Liu
Nov 3, 2020·Advanced Drug Delivery Reviews·Chao DengZhiyuan Zhong
Jun 18, 2021·Advanced Drug Delivery Reviews·Xi HuDaishun Ling
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danielle M Beaupre, Richard G Weiss
Oct 30, 2019·Biomacromolecules·Huanli SunChao Deng
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xinming Li, Peng Liu
Nov 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaoyang TaoWeidong Fei
Nov 23, 2021·Frontiers in Bioengineering and Biotechnology·Juan YuFuxiang Chu

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