Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery

Biomaterials Science
Ming WuJingfeng Liu

Abstract

Dual and multi-stimuli responsive polymeric nanoparticles that respond to two or more signals can further improve drug release performance compared with nanoparticles that respond to a single stimulus. However, usage of such nanoparticles to deliver siRNA and chemotherapeutic drugs in a sequential manner are currently very rare; meanwhile, this technology is vital to optimize the efficacy of chemotherapy towards cancer cells with multidrug resistance. By loading o-nitrobenzyl ester derivative caged DOX (DOC) into the inner poly(lactic-co-glycolic acid) (PLGA) core and adsorbing siRNA of P-gp protein onto the cationic polymeric shell derived from a disulfide-containing alkyl modified polyethylenimine (C16-S-S-PEI), here, a reduction/photo dual responsive device (RPDRD) is successfully designed for programmed P-gp siRNA and doxorubicin delivery. The dual-stimuli design of the RPDRD allows tumor microenvironment-specific and rapid release of P-gp siRNA triggered by the enrichment of reducing agent glutathione (GSH, up to 10 mM) for reversal of drug resistance by initially suppressing P-gp protein expression in MCF/ADR cells and then selectively triggering drug release by external light for chemotherapy afterwards. The sequential r...Continue Reading

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Citations

Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florian GauthierFrançoise Debart
Nov 3, 2020·Biomaterials Science·Terence TieuAnna Cifuentes-Rius
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shirin MollazadehMostafa Yazdimamaghani
Oct 24, 2020·ACS Combinatorial Science·Milad AshrafizadehPooyan Makvandi
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Yi PengLushan Yu
May 4, 2021·Chemical Reviews·Ramya KumarTheresa M Reineke
Jun 11, 2021·ACS Applied Materials & Interfaces·Xing-Qun PuLiang-Yin Chu
Aug 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jian SunZhaowei Chen
Aug 14, 2020·Nano Today·Sepideh AhmadiMichael R Hamblin

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Methods Mentioned

BETA
electrophoresis
flow cytometry
nanoprecipitation
transmission electron microscopy
Assay
Fluorescence

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