Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE study

Journal of Hypertension
Michael H OlsenLIFE Study Investigators

Abstract

In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, reduced urine albumin/creatinine ratio (UACR) as well as regression of left ventricular hypertrophy have been associated with lower incidence of cardiovascular events. We wanted to investigate whether these prognostic improvements were independent. In 6679 hypertensive patients included in the LIFE study, we measured UACR, left ventricular hypertrophy by electrocardiography, serum cholesterol, plasma glucose and blood pressure after 2 weeks of placebo treatment and again after 1 year of anti-hypertensive treatment with either an atenolol- or a losartan-based regimen. During this first year of treatment, 77 patients encountered a non-fatal stroke or myocardial infarction and were excluded to avoid bias. During the next 3-4 years, 610 composite endpoints [cardiovascular death (n = 228), fatal or non-fatal myocardial infarction or stroke] were recorded. In Cox regression analyses, the composite endpoint was after adjustment for treatment allocation predicted by baseline logUACR [hazard ratio (HR) = 1.16 per 10-fold increase, P < 0.05], 1-year logUACR (HR = 1.29 per 10-fold increase), baseline Sokolow-Lyon voltage (HR = 1.01 per mm, both P < 0.001) an...Continue Reading

References

Dec 1, 1992·Circulation·M J RomanR B Devereux
Apr 3, 1990·The American Journal of Cardiology·M VogtB E Strauer
Aug 1, 1995·European Journal of Clinical Investigation·J S JensenB Feldt-Rasmussen
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J S Jensen
Jul 1, 1994·Journal of Diabetes and Its Complications·B Feldt-RasmussenJ S Jensen
Jun 26, 1993·BMJ : British Medical Journal·K Borch-JohnsenC E Mogensen
May 1, 1997·Journal of the American College of Cardiology·E C JonesM J Roman
May 29, 1998·Circulation·P W WilsonW B Kannel
Mar 5, 2002·Journal of Hypertension·Josep Redon, Bryan Williams
May 21, 2003·Hypertension·Giovanna LeonciniRoberto Pontremoli
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Richard B DevereuxBjörn Dahlöf

❮ Previous
Next ❯

Citations

May 31, 2007·The Canadian Journal of Cardiology·UNKNOWN Canadian Hypertension Education Program
Jul 9, 2011·International Journal of Epidemiology·George C M Siontis, John P A Ioannidis
Apr 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shiming ZhuQing H Meng
May 6, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Albert Mimran, Guilhem du Cailar
Jun 8, 2006·Heart·J S Jürgensen
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Francesca ViazziRoberto Pontremoli
Mar 12, 2008·Drugs & Aging·Ramnath DukkipatiRajnish Mehrotra
Apr 1, 2008·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Giuseppe Mancia
Jan 17, 2009·Current Hypertension Reports·Guilhem du Cailar, Albert Mimran
Apr 20, 2007·Current Hypertension Reports·Guilhem du Cailar, Albert Mimran
Dec 5, 2009·Clinical and Experimental Nephrology·UNKNOWN Japanese Society of Nephrology
Apr 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brendan B McCormickGreg Knoll
Aug 21, 2007·Lancet·Franz H MesserliEberhard Ritz
Dec 18, 2012·British Journal of Clinical Pharmacology·Christian OttRoland E Schmieder
Jan 10, 2012·Fundamental & Clinical Pharmacology·Faiez ZannadUNKNOWN ESC Working Group on CardioVascular Pharmacology and Drug Therapy
Jun 20, 2013·Blood Pressure·UNKNOWN Task Force for the management of arterial hypertension of the European Society of Hypertension, UNKNOWN Task Force for the management of arterial hypertension of the European Society of Cardiology
Oct 30, 2010·Journal of cardiology·Nobuyuki Shiba, Hiroaki Shimokawa
Feb 12, 2015·Journal of the American Society of Hypertension : JASH·Rudolph SchutteAletta E Schutte
Nov 6, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ian GrahamUNKNOWN European Atherosclerosis Society (EAS)
Oct 12, 2011·The Journal of International Medical Research·M Tanaka
Mar 15, 2006·Journal of Hypertension·Ralph B D'Agostino
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Niloofar NobakhthaghighiRobert W Schrier
May 31, 2008·Expert Review of Cardiovascular Therapy·Cesare CuspidiAlberto Zanchetti
May 1, 2010·Blood Pressure·Thomas Sehestedt, Michael H Olsen
Sep 17, 2011·Basic & Clinical Pharmacology & Toxicology·Kent L Christensen, Niels H Buus
Jul 3, 2009·The Open Cardiovascular Medicine Journal·Konstantinos TziomalosDimitri P Mikhailidis
Jul 5, 2013·Journal of Hypertension·Kristian Wachtell, Peter M Okin
Jan 24, 2008·Journal of Wound Care·M LöndahlJ Apelqvist
Nov 11, 2009·Expert Review of Cardiovascular Therapy·Benjamin J EpsteinRushab Choksi
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Dan ShanGuan J Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.