PMID: 8968026Dec 1, 1996Paper

Reductions in bone strength after fluoride treatment are not reflected in tissue-level acoustic measurements

Bone
C H TurnerT Hirano

Abstract

Acoustic velocity measurements are used to estimate tissue-level bone strength after fluoride therapy for osteoporosis. However, acoustic measurements provide information about elasticity, not strength, and bone elasticity does not necessarily correlate with bone strength at a tissue level. The current study was undertaken to evaluate the effects of fluoride treatment on tissue-level acoustic velocities, and to determine the relationship between acoustic velocity and bone strength measured in the femur, femoral neck, and spine. Young adult rabbits were treated with either 0 or 100 parts per million of fluoride in their drinking water for six months. After treatment, the bones were harvested for measurement of tissue fluoride, bone strength, and acoustic properties. Acoustic velocities were measured in the femoral midshaft using an acoustic microscope with a 50 MHz transducer. Both longitudinal and transverse velocities were measured. After the initial acoustic measurements the bone specimens were treated to remove either the organic matrix or mineral, and the acoustic measurements were repeated. Fluoride treatment increased bone fluoride levels 7-8 fold and reduced all biomechanical parameters. Most notably the fracture force o...Continue Reading

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Citations

Feb 24, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K J MukamalD S Siscovick
Aug 23, 2001·Ultrasound in Medicine & Biology·S S MehtaE Richer
Apr 15, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Stéphane BlouinPaul Roschger
Dec 17, 2014·Seminars in Nephrology·Pablo Ureña TorresMartine Cohen-Solal
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·K Raum
Jan 21, 2006·Physics in Medicine and Biology·Kay RaumPascal Laugier

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