Reductions in brain pericytes are associated with arteriovenous malformation vascular instability

Journal of Neurosurgery
Ethan A WinklerMichael T Lawton

Abstract

OBJECTIVEBrain arteriovenous malformations (bAVMs) are rupture-prone tangles of blood vessels with direct shunting of blood flow between arterial and venous circulations. The molecular and/or cellular mechanisms contributing to bAVM pathogenesis and/or destabilization in sporadic lesions have remained elusive. Initial insights into AVM formation have been gained through models of genetic AVM syndromes. And while many studies have focused on endothelial cells, the contributions of other vascular cell types have yet to be systematically studied. Pericytes are multifunctional mural cells that regulate brain angiogenesis, blood-brain barrier integrity, and vascular stability. Here, the authors analyze the abundance of brain pericytes and their association with vascular changes in sporadic human AVMs.METHODSTissues from bAVMs and from temporal lobe specimens from patients with medically intractable epilepsy (nonvascular lesion controls [NVLCs]) were resected. Immunofluorescent staining with confocal microscopy was performed to quantify pericytes (platelet-derived growth factor receptor-beta [PDGFRβ] and aminopeptidase N [CD13]) and extravascular hemoglobin. Iron-positive hemosiderin deposits were quantified with Prussian blue staini...Continue Reading

References

May 2, 2001·The Journal of Cell Biology·M HellströmC Betsholtz
Aug 10, 2002·The EMBO Journal·Maria EngeChrister Betsholtz
Dec 20, 2003·Neurosurgery·Sonomi SatoToshihito Ishikawa
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Oct 13, 2006·Nature·Claire M PeppiattDavid Attwell
Oct 15, 2010·Nature·Annika ArmulikChrister Betsholtz
Mar 15, 2011·Developmental Cell·Ethan A WinklerBerislav V Zlokovic
Aug 16, 2011·Developmental Cell·Annika ArmulikChrister Betsholtz
Oct 28, 2011·Nature Neuroscience·Ethan A WinklerBerislav V Zlokovic
Feb 7, 2012·Stroke; a Journal of Cerebral Circulation·Yi GuoUNKNOWN University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project
May 25, 2012·Nature·Robert D BellBerislav V Zlokovic
Aug 2, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ethan A WinklerBerislav V Zlokovic
Sep 4, 2012·Acta Neuropathologica·Ethan A WinklerBerislav V Zlokovic
Dec 4, 2012·Journal of Neurosurgery·Bradley A Gross, Rose Du
Dec 18, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Wanqiu ChenWilliam L Young
Dec 18, 2013·Nature Communications·Abhay P SagareBerislav V Zlokovic
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ethan A WinklerBerislav V Zlokovic
Mar 29, 2014·Nature·Catherine N HallDavid Attwell
May 20, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Husam E El GhousainRamesh Kumar
Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Patrick A MurphyRong A Wang
Mar 12, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew R HallidayBerislav V Zlokovic
Mar 13, 2015·Frontiers in Genetics·Jérémy ThalgottFranck Lebrin
Mar 21, 2015·Stroke; a Journal of Cerebral Circulation·Gerald B SchulzAndreas Fischer
Oct 16, 2015·Acta Neurochirurgica. Supplement·Rui ZhangHua Su
Nov 23, 2015·Cell·Zhen ZhaoBerislav V Zlokovic
Jan 1, 2015·Nature Reviews. Disease Primers·Michael T LawtonRobert F Spetzler
May 27, 2016·Nature Neuroscience·Melanie D SweeneyBerislav V Zlokovic
Nov 1, 2016·Nature Neuroscience·Anusha MishraDavid Attwell
Jan 31, 2017·Nature Neuroscience·Kassandra KislerBerislav V Zlokovic

❮ Previous
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Citations

May 9, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Laura B PayneJohn C Chappell
Jul 7, 2019·Journal of Cellular and Molecular Medicine·Caroline LeonelAlexander Birbrair
Jul 31, 2019·CNS Neuroscience & Therapeutics·Sonali S ShaligramHua Su
Sep 10, 2019·Stroke; a Journal of Cerebral Circulation·Turgay Dalkara
Feb 7, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Takahiro Ota, Masaki Komiyama
May 21, 2020·Neurosurgery·Daniel M S RaperAdib A Abla
Jun 22, 2020·Clinical and Translational Medicine·Lorelei D ShoemakerSteven D Chang
Jun 14, 2020·Molecular Oncology·Kinga MolnárImola Wilhelm
Aug 21, 2020·Cephalalgia : an International Journal of Headache·Laura L LehmanRami Burstein
Nov 17, 2019·International Journal of Molecular Sciences·Leandro Barbosa Do PradoHua Su
Dec 12, 2019·Frontiers in Cellular Neuroscience·Xiaojuan SuDezhi Mu
Apr 5, 2020·Neural Regeneration Research·Jun-Mou HongChao-Liang Tang
Jul 18, 2020·Fluids and Barriers of the CNS·Anuska V AndjelkovicRichard F Keep
Oct 17, 2019·Frontiers in Cellular Neuroscience·Andres Villabona-RuedaMonique F Stins
Aug 2, 2018·Frontiers in Aging Neuroscience·Andrée-Anne BerthiaumeAndy Y Shih
Mar 27, 2019·Annals of Clinical and Translational Neurology·Marco A StefaniJay P Mohr
Jul 22, 2019·Journal of Molecular Neuroscience : MN·Xiaosheng ChenYi Huang
Nov 10, 2020·Science China. Life Sciences·Ya-Na GuanQing Jing
Dec 22, 2020·Journal of Cellular Physiology·S Krithika, S Sumi
Dec 22, 2020·Frontiers in Physiology·Jayden M RossEthan A Winkler
Mar 22, 2021·Fluids and Barriers of the CNS·Francesco GirolamoDaniela Virgintino
Jun 25, 2021·Circulation Research·Justin RustenhovenJonathan Kipnis
Jun 25, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peipei PanHua Su
Dec 8, 2021·Journal of Neurointerventional Surgery·Zhipeng LiYuanli Zhao

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

syngo iFlow
ImageJ
iFlow

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