Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors

Progress in Neuro-psychopharmacology & Biological Psychiatry
Buqing YiAlexander Choukèr

Abstract

Increasing evidence indicates that chronic stress, such as social isolation, plays an important role in the development of a variety of psychiatric and somatic disorders. Meanwhile, chronic stress imposed by prolonged isolation and confinement in the spacecraft is also one of the major concerns for the health of future interplanetary space travelers. Preclinical studies suggest that the peripheral endocannabinoid (eCB) system is involved in the regulation of the stress response and eCB signaling is implicated in the pathogenesis of stress-related diseases. However, there are only few human studies addressing this topic, of which most focusing on patients who have already developed a certain type of disorder. It remains unknown whether chronic stress may affect eCB signaling in healthy humans. A 520-d isolation and confinement study simulating a flight to Mars provided an extraordinary chance to study the effects of prolonged stress in healthy humans. During the study period, the participants lived in confinement and could not meet their families, friends, or strangers for more than 500 days. We examined the impact of chronic exposure to isolation and confinement through monitoring their psychological state, brain cortical activ...Continue Reading

References

Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Dec 22, 1999·Biological Psychiatry·J F LópezS J Watson
Oct 7, 2004·The Lancet Oncology·Edna Maria Vissoci ReicheHelena Kaminami Morimoto
Nov 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillBoris B Gorzalka
Mar 25, 2005·The European Journal of Neuroscience·Sachin PatelCecilia J Hillard
Jan 1, 1997·Journal of Personality Assessment·D Watson, L A Clark
Apr 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Michael VogeserGustav Schelling
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Sheldon CohenGregory E Miller
Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthew N Hill, Bruce S McEwen
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barun K ChoudhurySushil K Sarna
Jul 3, 2009·Neuroimmunomodulation·George P ChrousosEvangelia Charmandari
Sep 8, 2009·Trends in Pharmacological Sciences·Matthew N HillGabriella Gobbi
Nov 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthew N Hill, Bruce S McEwen
Jan 2, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sarah A EisensteinAndrea G Hohmann
Mar 30, 2010·Behavioural Brain Research·Stefan SchneiderHeiko K Strüder
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew N HillJaideep S Bains
Jun 15, 2011·Stress : the International Journal on the Biology of Stress·Caitlin J Riebe, Carsten T Wotjak
Aug 11, 2011·Neuroscience·R J McLaughlin, G Gobbi
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Piray AtsakBenno Roozendaal
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sheldon CohenRonald B Turner
Oct 19, 2013·The Proceedings of the Nutrition Society·Roger G Pertwee
May 20, 2015·Biological Psychiatry·Imke JennichesAndreas Zimmer
May 28, 2015·Physiological Measurement·J F AlonsoM A Mañanas

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Citations

Jun 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecilia J Hillard
Apr 10, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kirsten R Müller-VahlKurt-Wolfram Sühs
Feb 6, 2016·Journal of Applied Physiology·J I Pagel, A Choukèr
Dec 15, 2020·Nature Communications·Grégoire ChevalierPierre-Marie Lledo
Jul 26, 2017·Frontiers in Neuroendocrinology·Georgia BalsevichMatthew N Hill
Aug 30, 2020·Brain, Behavior, and Immunity·Zuzanna ZajkowskaCarmine M Pariante
Aug 4, 2019·Psychiatry Research·Leo SherRachel Yehuda
Apr 28, 2021·Basic & Clinical Pharmacology & Toxicology·Kennia M SilveiraSâmia R L Joca

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